2. Epigenetics Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Histone Methyltransferase HSP
  4. SGC8158

SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC50: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity.

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SGC8158

SGC8158 Chemische Struktur

CAS. Nr. : 3062376-84-2

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SGC8158 Related Antibodies

Top Publications Citing Use of Products

Alle Histone Methyltransferase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

Alle HSP Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

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Beschreibung

SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7. SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC50: 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin (HY-15142A) induced DNA damage and Its cytotoxicity[1].

IC50 & Target[1]

PRMT7

 

Molekulargewicht

555.09

Formel

C27H31ClN6O3S
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1CSCCCCNCC4=CC=CC(C5=CC=C(Cl)C=C5)=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Reinheit & Dokumentation

Purity: 97.6%

SDS (252 KB)

COA (246 KB)

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SGC8158 Related Classifications

  • Molaritätsrechner

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Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGC81583062376-84-2SGC 8158SGC-8158Histone MethyltransferaseHSPHeat shock proteinsanti-proliferativeMDRDNA damagePRMT7 substrateInhibitorinhibitorinhibit

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