SM-360320 (Synonyms: CL-087)

Cat. No.: HY-125390 Purity: 99.41%: Data Sheet
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SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity.

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SM-360320 화학구조

CAS No. : 226907-52-4

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

Biological Activity
순도&문서
References
고객리뷰

제품 설명

SM-360320 (CL-087) is a potent, orally active TLR7 agonist. SM-360320 is a immuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response^[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	1.17 μM Compound: SM360320	Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells assessed as induction of NFKappaB activity after 24 hrs by SEAP reporter gene assay	[PMID: 32001135]
HEK293	EC₅₀	399.4 nM Compound: 3	Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay Agonist activity at human TLR7 expressed in HEK293 cells coexpressing pNiFty2-SEAP reporter by reporter gene assay	[PMID: 20232824]
Huh-7	EC₅₀	30 nM Compound: BHMA	Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay Antiviral activity against HCV infected in human Huh7 cells with persistent PFK1389-Luc-Ubi-Neo-NS3-3'/ET replicon after 48 hrs by luminescence based assay	[PMID: 20028817]
PBMC	EC₅₀	0.14 μM Compound: 4, SM360320	Induction of IFNalpha production in human PBMC Induction of IFNalpha production in human PBMC	[PMID: 16784848]

분자량

315.33

화학식

C₁₅H₁₇N₅O₃

CAS No.

226907-52-4

Appearance

Solid

Color

White to off-white

SMILES

COCCOC1=NC(N)=C2C(N(C(N2)=O)CC3=CC=CC=C3)=N1

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 125 mg/mL (396.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1713 mL	15.8564 mL	31.7128 mL
5 mM	0.6343 mL	3.1713 mL	6.3426 mL
10 mM	0.3171 mL	1.5856 mL	3.1713 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.41%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) HNMR (240 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. [Content Brief]

[2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1713 mL	15.8564 mL	31.7128 mL	79.2820 mL
	5 mM	0.6343 mL	3.1713 mL	6.3426 mL	15.8564 mL
	10 mM	0.3171 mL	1.5856 mL	3.1713 mL	7.9282 mL
	15 mM	0.2114 mL	1.0571 mL	2.1142 mL	5.2855 mL
	20 mM	0.1586 mL	0.7928 mL	1.5856 mL	3.9641 mL
	25 mM	0.1269 mL	0.6343 mL	1.2685 mL	3.1713 mL
	30 mM	0.1057 mL	0.5285 mL	1.0571 mL	2.6427 mL
	40 mM	0.0793 mL	0.3964 mL	0.7928 mL	1.9821 mL
	50 mM	0.0634 mL	0.3171 mL	0.6343 mL	1.5856 mL
	60 mM	0.0529 mL	0.2643 mL	0.5285 mL	1.3214 mL
	80 mM	0.0396 mL	0.1982 mL	0.3964 mL	0.9910 mL
	100 mM	0.0317 mL	0.1586 mL	0.3171 mL	0.7928 mL

SM-360320 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SM-360320226907-52-4CL-087SM360320SM 360320CL087CL 087Toll-like Receptor (TLR)oralTLR7antitumor effectDNA vaccinesTh1Inhibitorinhibitorinhibit

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SM-360320 (Synonyms: CL-087)

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SM-360320 Related Antibodies

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•Related Screening Libraries:

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View All Toll-like Receptor (TLR) Isoform Specific Products:

Biological Activity

순도&문서

References

고객리뷰

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

SM-360320 Related Classifications

Keywords:

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SAFETY DATA SHEET (SDS)

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