SMARCA-BD ligand 1 for PROTAC hydrochloride

Name: SMARCA-BD ligand 1 for PROTAC hydrochloride
Brand: MedChemExpress
SKU: HY-44012B
Rating: 4.5 (1 reviews)

Cat. No.: HY-44012B Pureza: 99.24%: Ficha de datos
COA

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SMARCA-BD ligand 1 hydrochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

Para uso exclusivo en investigación. No vendemos a pacientes.

SMARCA-BD ligand 1 for PROTAC hydrochloride Estructura química

No. CAS : 2380272-56-8

Tamaño	Stock	Cantidad

Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of SMARCA-BD ligand 1 for PROTAC hydrochloride:

SMARCA-BD ligand 1 for PROTAC In-stock
SMARCA-BD ligand 1 for PROTAC dihydrochloride In-stock

1 Publications Citing Use of MCE SMARCA-BD ligand 1 for PROTAC hydrochloride

•Cell Chem Biol. 2024 Oct 1:S2451-9456(24)00396-9. [Abstract]

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Ver todas las isoformas

SMARCA2 SMARCA4 Protein Polybromo-1

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

SMARCA-BD ligand 1 hydrochloride for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC^[1].

IC₅₀ & Target^[1]

SMARCA2

SMARCA4

PBRM1

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

307.78

Fòrmula

C₁₄H₁₈ClN₅O

No. CAS

2380272-56-8

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2.[H]Cl

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 10 mg/mL (32.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2491 mL	16.2454 mL	32.4907 mL
5 mM	0.6498 mL	3.2491 mL	6.4981 mL
10 mM	0.3249 mL	1.6245 mL	3.2491 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.24%

Select Batch:

Ficha de datos (274 KB) SDS (252 KB)

COA (251 KB) HNMR (329 KB) LCMS (330 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2491 mL	16.2454 mL	32.4907 mL	81.2269 mL
	5 mM	0.6498 mL	3.2491 mL	6.4981 mL	16.2454 mL
	10 mM	0.3249 mL	1.6245 mL	3.2491 mL	8.1227 mL
	15 mM	0.2166 mL	1.0830 mL	2.1660 mL	5.4151 mL
	20 mM	0.1625 mL	0.8123 mL	1.6245 mL	4.0613 mL
	25 mM	0.1300 mL	0.6498 mL	1.2996 mL	3.2491 mL
	30 mM	0.1083 mL	0.5415 mL	1.0830 mL	2.7076 mL