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Cat. No.: HY-13300A

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SR-3677 dihydrochloride

Name: SR-3677 dihydrochloride
Brand: MedChemExpress
SKU: HY-13300A
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC₅₀ values of 56 nM and 3 nM.

For research use only. We do not sell to patients.

CAS No.: 1781628-88-3
Formula: C₂₂H₂₆Cl₂N₄O₄
Molecular Weight:481.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SR-3677 dihydrochloride Chemical Structure

CAS No.: 1781628-88-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

SR-3677 dihydrochloride (compound 5) is a potent and selective ROCK-I and ROCK-II inhibitor with an IC₅₀ values of 56 nM and 3 nM^[1].

IC₅₀ & Target

ROCK-I

56 nM (IC₅₀)

ROCK-II

3 nM (IC₅₀)

All ROCK Isoforms :

Chemical Information

CAS No. 1781628-88-3
Molecular Weight 481.37
Formula C₂₂H₂₆Cl₂N₄O₄
SMILES

[H]Cl.[H]Cl.CN(C)CCOC1=C(NC(C2OC(C=CC=C3)=C3OC2)=O)C=CC(C4=CNN=C4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Patent

US20180263995A1.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

SR-3677 dihydrochloride

1 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (1)
Protocols
Purity & Documentation
References

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SR-3677 dihydrochloride

Publications Citing Use of MedChemExpress (MCE) SR-3677 dihydrochloride

All ROCK Isoforms