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Cat. No.: HY-184392

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SR 59230

SR 59230 is a β₃-adrenergic receptor antagonist, and its four stereoisomers exhibit biological activity against different β-adrenergic receptor subtypes. SR 59230 partially inhibits lipolysis in rat adipocytes but shows no inhibitory effect on this process in human adipocytes, displaying species selectivity. SR 59230 can be used for studies on mechanisms related to β-adrenergic receptor subtypes.

For research use only. We do not sell to patients.

CAS No.: 174689-38-4
Formula: C₂₁H₂₇NO₂
Molecular Weight:325.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SR 59230 Chemical Structure

CAS No.: 174689-38-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target^[1]

Beta-3 adrenergic receptor

All Adrenergic Receptor Isoforms :

In Vitro

SR 59230 oxalate form, SR 59230A, inhibits cloned cardiac potassium channels Kir2.1, Kir-2.2 and Kir-2.3^[1].
SR 59230 consists of four stereoisomers, all of which exhibit differential biological activities against different β-adrenergic receptor subtypes in cellular assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 174689-38-4
Molecular Weight 325.44
Formula C₂₁H₂₇NO₂
SMILES

CCC(C=CC=C1)=C1OC[C@@H](O)CN[C@@H]2C3=CC=CC=C3CCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bredikhina Z A, et al. Synthesis of all of the stereoisomers of β3-adrenoceptor antagonist SR 59230 based on the spontaneous resolution of 3-(2-ethylphenoxy)propane-1,2-diol. Tetrahedron: Asymmetry. 2016;27:467-474.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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SR 59230

All Adrenergic Receptor Isoforms