SST0116CL1 free base
SST0116CL1 free base is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 free base binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma.
For research use only. We do not sell to patients.
- CAS No.: 1202920-93-1
- Formula: C22H30N4O6
- Molecular Weight:446.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HSP90 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L6 | IC50 |
146 nM
Compound: 1a
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Cytotoxicity against rat L6 cells
Cytotoxicity against rat L6 cells
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[PMID: 25547934] |
| NCI-H460 | IC50 |
0.11 μM
Compound: 79b
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Cytotoxicity against human NCI-H460 after 72 hrs by sulforhodamine B assay
Cytotoxicity against human NCI-H460 after 72 hrs by sulforhodamine B assay
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[PMID: 22066525] |
SST0116CL1 has antiproliferative activity on different tumor cell lines, with IC50s of 0.81 μM (A431), 0.11 μM (NCI-H460), 0.81 μM (A2780), 0.40 μM (MV4;11), 0.23 μM (GTL-16), 0.62 μM (BT474), 0.34 μM (HT-1080)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1202920-93-1
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Molecular Weight 446.50
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Formula C22H30N4O6
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SMILES
O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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