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Cat. No.: HY-164399A

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SST0116CL1 free base

SST0116CL1 free base is a HSP90 inhibitor (IC₅₀: 0.21 μM). SST0116CL1 free base binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC₅₀: 0.2 μM). SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma.

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CAS No.: 1202920-93-1
화학식: C₂₂H₃₀N₄O₆
분자량:446.50

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SST0116CL1 free base Chemical Structure

CAS No.: 1202920-93-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

HSP90

All HSP Isoforms :

All ERK Isoforms :

All CDK Isoforms :

All Akt Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
L6	IC₅₀	146 nM Compound: 1a	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 25547934]
NCI-H460	IC₅₀	0.11 μM Compound: 79b	Cytotoxicity against human NCI-H460 after 72 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 after 72 hrs by sulforhodamine B assay	[PMID: 22066525]

In Vitro

SST0116CL1 has antiproliferative activity on different tumor cell lines, with IC₅₀s of 0.81 μM (A431), 0.11 μM (NCI-H460), 0.81 μM (A2780), 0.40 μM (MV4;11), 0.23 μM (GTL-16), 0.62 μM (BT474), 0.34 μM (HT-1080)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1202920-93-1
분자량 446.50
화학식 C₂₂H₃₀N₄O₆
SMILES

O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vesci L, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor. Int J Oncol. 2014 Oct;45(4):1421-9. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

SST0116CL1 free base

All HSP Isoforms

All ERK Isoforms

All CDK Isoforms

All Akt Isoforms