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Cat. No.: HY-143321

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STING agonist-13

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

STING agonist-13 is a stimulator of interferon genes (STING) agonist, for cancer immunity via STING-mediated immune activation. STING agonist-13 can stimulate STING downstream signaling and promoting type I interferon immune responses. STING agonist-13 significantly decreases tumor volume and shows immunological memory-derived cancer inhibition.

For research use only. We do not sell to patients.

CAS No.: 2816929-48-1
Formula: C₄₅H₅₃N₁₅O₇
Molecular Weight:916.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

STING agonist-13 Chemical Structure

CAS No.: 2816929-48-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EC50: 7.471 nM (PBMCs), 2.442 nM (RAW264.7)^[1]

In Vitro

STING agonist-13 (compound 4c) induces the secretion of IFN-β with an EC₅₀ of 7.471 nM in human primary PBMCs cells^[1].
STING agonist-13 (2 μM; 24 hours) induces IP-10 with an EC₅₀ of 2.442 nM and other proinflammatory cytokines such as IL-6 and TNF-α release in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PBMCs, RAW264.7
Concentration:

2 μM
Incubation Time:

24 hours
Result:

Showed broad reactivity in PBMCs and RAW264.7 cells.

In Vivo

STING agonist-13 (compound 4c; 1.5 mg/kg; i.v.; once a day for 8 days) suppresses tumor growth and can prevent tumor recurrence by immune activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

8 week-old female BALB/c mice(CT26 tumor mouse models)^[1]
Dosage:

1.5 mg/kg
Administration:

Intravenous injection; once a day for 8 days.
Result:

Showed activity of cancer immunity via STING-mediated immune activation.

Chemical Information

CAS No. 2816929-48-1
Molecular Weight 916.00
Formula C₄₅H₅₃N₁₅O₇
SMILES

CCN1N=C(C=C1C(NC2=NC3=C(N2C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)=NC6=CC(C(N)=O)=CC(OCCCNC(C7=CC(C)=NN7CC)=O)=C64)C(OC)=CC(C(N)=O)=C3)=O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Signal Transduct Target Ther

Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction. [Abstract]

2025 May 28;10(1):167. PMID: 40425583

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jeon MJ, L, et al. Development of Potent Immune Modulators Targeting Stimulator of Interferon Genes Receptor. J Med Chem. 2022 Apr 14;65(7):5407-5432. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

STING agonist-13

1 Cited Publications

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Biological Activity
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- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

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STING agonist-13

Publications Citing Use of MedChemExpress (MCE) STING agonist-13

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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STING agonist-13 Related Classifications

HY-143321 Related Classifications