Taltobulin intermediate-1

Cat. No.: HY-41047 Purity: 96.53%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Taltobulin intermediate-1 is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis.

For research use only. We do not sell to patients.

Taltobulin intermediate-1 Chemical Structure

CAS No. : 228266-38-4

Size	Price	Stock	Quantity
50 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 330	In-stock	Estimated Time of Arrival: December 31
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Other Forms of Taltobulin intermediate-1:

(Rac)-Taltobulin intermediate-1 In-stock

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Description

Molecular Weight

307.38

Formula

C₁₇H₂₅NO₄

CAS No.

228266-38-4

Appearance

Oil

Color

Colorless to light yellow

SMILES

OC([C@@H](N(C(OC(C)(C)C)=O)C)C(C)(C)C1=CC=CC=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 200 mg/mL (650.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2533 mL	16.2665 mL	32.5330 mL
5 mM	0.6507 mL	3.2533 mL	6.5066 mL
10 mM	0.3253 mL	1.6267 mL	3.2533 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (16.27 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (16.27 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (16.27 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.07% ee.: 100.00%

Select Batch:

Data Sheet (246 KB) SDS (393 KB)

COA (252 KB) HNMR (315 KB) NP-HPLC (225 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2533 mL	16.2665 mL	32.5330 mL	81.3326 mL
	5 mM	0.6507 mL	3.2533 mL	6.5066 mL	16.2665 mL
	10 mM	0.3253 mL	1.6267 mL	3.2533 mL	8.1333 mL
	15 mM	0.2169 mL	1.0844 mL	2.1689 mL	5.4222 mL
	20 mM	0.1627 mL	0.8133 mL	1.6267 mL	4.0666 mL
	25 mM	0.1301 mL	0.6507 mL	1.3013 mL	3.2533 mL
	30 mM	0.1084 mL	0.5422 mL	1.0844 mL	2.7111 mL
	40 mM	0.0813 mL	0.4067 mL	0.8133 mL	2.0333 mL
	50 mM	0.0651 mL	0.3253 mL	0.6507 mL	1.6267 mL
	60 mM	0.0542 mL	0.2711 mL	0.5422 mL	1.3555 mL
	80 mM	0.0407 mL	0.2033 mL	0.4067 mL	1.0167 mL
	100 mM	0.0325 mL	0.1627 mL	0.3253 mL	0.8133 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taltobulin intermediate-1228266-38-4Taltobulin intermediate1Taltobulin intermediate 1Inhibitorinhibitorinhibit

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Taltobulin intermediate-1

Other Forms of Taltobulin intermediate-1: