2. Others
  3. Insecticide
  4. TBZ-15

TBZ-15 is an orally active competitive Chitinase inhibitor and Insecticide, with an IC50 of 1.00 μM against Ostrinia furnacalis Chitinase-h and an IC50 of 1.01 μM against Ostrinia furnacalis Chitinase-I. TBZ-15 exhibits insecticidal activity against the Asian corn borer (O. furnacalis) and the diamondback moth (P. xylostella).

For research use only. We do not sell to patients.

TBZ-15

TBZ-15 Chemical Structure

CAS No. : 892237-40-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

TBZ-15 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TBZ-15 is an orally active competitive Chitinase inhibitor and Insecticide, with an IC50 of 1.00 μM against Ostrinia furnacalis Chitinase-h and an IC50 of 1.01 μM against Ostrinia furnacalis Chitinase-I. TBZ-15 exhibits insecticidal activity against the Asian corn borer (O. furnacalis) and the diamondback moth (P. xylostella)[1].

In Vitro

TBZ-15 (0.36-10 μM; 10 min preincubation, 20 min incubation with substrate) potently acts as a competitive dual inhibitor of purified Ostrinia furnacalis Of Chi-h (Ki = 0.64 μM) and Of ChtI (Ki = 0.43 μM) enzymes, with IC50 values of 1.00 μM and 1.01 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TBZ-15 Related Antibodies
In Vivo

TBZ-15 (10 μM; incorporated into artificial diet; continuous feeding; 6 days) inhibits O. furnacalis larval growth by reducing body weight by 33% and body length by 23%, and induces abnormal cuticular development after 6 days of continuous feeding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ostrinia furnacalis (third-instar day 1 larvae)[1]
Dosage: 10 μM
Administration: incorporated into artificial diet; continuous feeding; 6 days
Result: Reduced larval body weight by 33% compared to controls.
Reduced larval body length by 23% compared to controls.
Induced darkening of the dorsal region, abnormal epidermal stratification, slow crawling, loss of orientation, and insensitivity to external stimuli.
Caused prominent dorsal cuticle folds, enlarged chitin granules, and tighter, irregular arrangement of cuticular structures.
Molecular Weight

463.41

Formula

C19H19BrN4OS2
CAS No.
SMILES

BrC1=CC=C(NC(C2=CSC=C2)OC3=C4N=NC(SCCCCC)=N3)C4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TBZ-15 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TBZ-15892237-40-0TBZ15TBZ 15Insecticideinsect growth inhibitorPlutella xylostellachitinchitinase-encoding geneschitinasesOstrinia furnacalis Chitinase-IinsecticideT. ostriniaeOstrinia furnacalis Chitinase-hOstrinia furnacalisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TBZ-15
Cat. No.:
HY-184009
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.