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Cat. No.: HY-184009

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TBZ-15

TBZ-15 is an orally active competitive Chitinase inhibitor and Insecticide, with an IC₅₀ of 1.00 μM against Ostrinia furnacalis Chitinase-h and an IC₅₀ of 1.01 μM against Ostrinia furnacalis Chitinase-I. TBZ-15 exhibits insecticidal activity against the Asian corn borer (O. furnacalis) and the diamondback moth (P. xylostella).

For research use only. We do not sell to patients.

CAS No.: 892237-40-0
Formula: C₁₉H₁₉BrN₄OS₂
Molecular Weight:463.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TBZ-15 Chemical Structure

CAS No.: 892237-40-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

In Vitro

TBZ-15 (0.36-10 μM; 10 min preincubation, 20 min incubation with substrate) potently acts as a competitive dual inhibitor of purified Ostrinia furnacalis Of Chi-h (K_i = 0.64 μM) and Of ChtI (K_i = 0.43 μM) enzymes, with IC₅₀ values of 1.00 μM and 1.01 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TBZ-15 (10 μM; incorporated into artificial diet; continuous feeding; 6 days) inhibits O. furnacalis larval growth by reducing body weight by 33% and body length by 23%, and induces abnormal cuticular development after 6 days of continuous feeding^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ostrinia furnacalis (third-instar day 1 larvae)^[1]
Dosage:

10 μM
Administration:

incorporated into artificial diet; continuous feeding; 6 days
Result:

Reduced larval body weight by 33% compared to controls.
Reduced larval body length by 23% compared to controls.
Induced darkening of the dorsal region, abnormal epidermal stratification, slow crawling, loss of orientation, and insensitivity to external stimuli.
Caused prominent dorsal cuticle folds, enlarged chitin granules, and tighter, irregular arrangement of cuticular structures.

Chemical Information

CAS No. 892237-40-0
Molecular Weight 463.41
Formula C₁₉H₁₉BrN₄OS₂
SMILES

BrC1=CC=C(NC(C2=CSC=C2)OC3=C4N=NC(SCCCCC)=N3)C4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang J, et al. Triazinobenzoxazepine Derivatives Identified as Dual-Chitinase Inhibitors to Regulate Insect Growth. J Agric Food Chem. 2026;74(21):16124-16134. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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