TBZ-15
TBZ-15 is an orally active competitive Chitinase inhibitor and Insecticide, with an IC50 of 1.00 μM against Ostrinia furnacalis Chitinase-h and an IC50 of 1.01 μM against Ostrinia furnacalis Chitinase-I. TBZ-15 exhibits insecticidal activity against the Asian corn borer (O. furnacalis) and the diamondback moth (P. xylostella).
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- CAS. Nr.: 892237-40-0
- Formel: C19H19BrN4OS2
- Molecular Weight:463.41
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Biologische Aktivität
Beschreibung
In Vitro
TBZ-15 (0.36-10 μM; 10 min preincubation, 20 min incubation with substrate) potently acts as a competitive dual inhibitor of purified Ostrinia furnacalis Of Chi-h (Ki = 0.64 μM) and Of ChtI (Ki = 0.43 μM) enzymes, with IC50 values of 1.00 μM and 1.01 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ostrinia furnacalis (third-instar day 1 larvae)[1]
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Dosage:10 μM
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Administration:incorporated into artificial diet; continuous feeding; 6 days
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Result:Reduced larval body weight by 33% compared to controls.
Reduced larval body length by 23% compared to controls.
Induced darkening of the dorsal region, abnormal epidermal stratification, slow crawling, loss of orientation, and insensitivity to external stimuli.
Caused prominent dorsal cuticle folds, enlarged chitin granules, and tighter, irregular arrangement of cuticular structures.
Chemical Information
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CAS. Nr. 892237-40-0
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Molecular Weight 463.41
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Formel C19H19BrN4OS2
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SMILES
BrC1=CC=C(NC(C2=CSC=C2)OC3=C4N=NC(SCCCCC)=N3)C4=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TBZ-15 Related Classifications
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