TC-N 1752 (Standard)
TC-N 1752 (Standard) is the analytical standard of TC-N 1752 (HY-107405). This product is intended for research and analytical applications. TC-N 1752 is a potent and orally active inhibitor of Nav1.7, with IC50s of 0.17 μM, 0.3 μM, 0.4 μM, 1.1 μM and 2.2 μM at hNav1.7, hNav1.3, hNav1.4, hNaV1.5 and rNav1.8, respectively. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. TC-N 1752 shows analgesic efficacy in the Formalin model of pain.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 1211866-85-1
- Formule: C25H27F3N6O3
- Masse moléculaire:516.52
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
-
HY-11079
A-803467Nav1.8 Sodium Channel Blocker -
HY-B0387
Ibutilide fumarateAnti-arrhythmic Agent -
HY-107405
TC-N 1752Nav1.7 Inhibitor -
HY-B0246
CarbamazepineAnticonvulsant -
HY-N6691
VeratridineVGSCs Agonist -
HY-B0211
RiluzoleAnticonvulsant Agent -
HY-B0495
LamotrigineAnticonvulsant Agent -
HY-19693
CariporideNa+/H+ Exchange Inhibitor -
HY-B0114
OxcarbazepineAnti-Epileptic Agent -
HY-108505
QX-314 chlorideSodium Channel Blocker -
HY-B0246R
Carbamazepine (Standard)Anticonvulsant
Activité biologique
Description
Chemical Information
-
CAS No. 1211866-85-1
-
Masse moléculaire 516.52
-
Formule C25H27F3N6O3
-
SMILES
FC(F)(F)OC(C=C1)=CC=C1COC(CC2)CCN2C3=NC=NC(NC4=C(C(NC(C)=O)=CC=C4)C)=N3
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Bregman H, et, al. Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain. J Med Chem. 2011 Jul 14;54(13):4427-45. [Content Brief]
[2]. Lin Z, et, al. Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells. PLoS One. 2016 Aug 24;11(8):e0161450. [Content Brief]
[3]. Matson DJ, et, al. Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain. PLoS One. 2015 Sep 17;10(9):e0138140. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TC-N 1752 (Standard) Related Classifications
HY-107405R Related Classifications
Powered by Bioz