Tetrafluoro-thalidomide
Tetrafluoro-thalidomide is a fluorinated Thalidomide analogue. Tetrafluoro-thalidomide is an activator of E3 ligase, which ubiquitinylates proteins for later proteolysis. The structure may be further derivatized via substitution at its fluorines.
For research use only. We do not sell to patients.
- CAS No.: 179033-21-7
- Formula: C13H6F4N2O4
- Molecular Weight:330.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
3.2 μM
Compound: 2
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Antiangiogenesis activity in HUVEC cells assessed as inhibition of tube formation measured after 18 hrs
Antiangiogenesis activity in HUVEC cells assessed as inhibition of tube formation measured after 18 hrs
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[PMID: 38917956] |
| THP-1 | IC50 |
490 nM
Compound: 2
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Inhibition of LPS-induced Tumor necrosis factor-alpha production (TNF-alpha) in THP-1 cells
Inhibition of LPS-induced Tumor necrosis factor-alpha production (TNF-alpha) in THP-1 cells
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[PMID: 9871710] |
Chemical Information
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CAS No. 179033-21-7
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Molecular Weight 330.19
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Formula C13H6F4N2O4
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SMILES
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(F)=C(F)C(F)=C2F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetrafluoro-thalidomide Related Classifications
HY-172295 Related Classifications
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