Tetrafluoro-thalidomide
Tetrafluoro-thalidomide is a fluorinated Thalidomide analogue. Tetrafluoro-thalidomide is an activator of E3 ligase, which ubiquitinylates proteins for later proteolysis. The structure may be further derivatized via substitution at its fluorines.
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- CAS. Nr.: 179033-21-7
- Formel: C13H6F4N2O4
- Molecular Weight:330.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
3.2 μM
Compound: 2
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Antiangiogenesis activity in HUVEC cells assessed as inhibition of tube formation measured after 18 hrs
Antiangiogenesis activity in HUVEC cells assessed as inhibition of tube formation measured after 18 hrs
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[PMID: 38917956] |
| THP-1 | IC50 |
490 nM
Compound: 2
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Inhibition of LPS-induced Tumor necrosis factor-alpha production (TNF-alpha) in THP-1 cells
Inhibition of LPS-induced Tumor necrosis factor-alpha production (TNF-alpha) in THP-1 cells
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[PMID: 9871710] |
Chemical Information
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CAS. Nr. 179033-21-7
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Molecular Weight 330.19
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Formel C13H6F4N2O4
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SMILES
O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(F)=C(F)C(F)=C2F
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Tetrafluoro-thalidomide Related Classifications
HY-172295 Related Classifications
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