2. Anti-infection
  3. SARS-CoV
  4. TH1217

TH1217  (Synonyms: ZINC1775962367)

Cat. No.: HY-135909 Purity: 99.73%
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TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.

For research use only. We do not sell to patients.

TH1217 Chemical Structure

TH1217 Chemical Structure

CAS No. : 1862212-48-3

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Based on 1 publication(s) in Google Scholar

TH1217 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TH1217

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2].

IC50 & Target

IC50: 47 nM (dCTPase)[1]
In Vitro

TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%)[1].
TH1217 presents suitable mouse microsomal half-lives (109 minutes)[1].
TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TH1217 Related Antibodies
Molecular Weight

491.09

Formula

C20H17BCl2N4O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=NC2=C(C(Cl)=C(Cl)C=C2N1CC3=CC=C(C=C3)[B-]45OC(C[N+]4(C)CC(O5)=O)=O)[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (254.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0363 mL 10.1814 mL 20.3629 mL
5 mM 0.4073 mL 2.0363 mL 4.0726 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0363 mL 10.1814 mL 20.3629 mL 50.9072 mL
5 mM 0.4073 mL 2.0363 mL 4.0726 mL 10.1814 mL
10 mM 0.2036 mL 1.0181 mL 2.0363 mL 5.0907 mL
15 mM 0.1358 mL 0.6788 mL 1.3575 mL 3.3938 mL
20 mM 0.1018 mL 0.5091 mL 1.0181 mL 2.5454 mL
25 mM 0.0815 mL 0.4073 mL 0.8145 mL 2.0363 mL
30 mM 0.0679 mL 0.3394 mL 0.6788 mL 1.6969 mL
40 mM 0.0509 mL 0.2545 mL 0.5091 mL 1.2727 mL
50 mM 0.0407 mL 0.2036 mL 0.4073 mL 1.0181 mL
60 mM 0.0339 mL 0.1697 mL 0.3394 mL 0.8485 mL
80 mM 0.0255 mL 0.1273 mL 0.2545 mL 0.6363 mL
100 mM 0.0204 mL 0.1018 mL 0.2036 mL 0.5091 mL
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TH1217 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TH12171862212-48-3ZINC1775962367TH 1217TH-1217ZINC 1775962367ZINC-1775962367SARS-CoVSARS coronavirusdCTPasepyrophosphataseleukemiaSARS-Cov-2COVID-19Inhibitorinhibitorinhibit

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