1. Anti-infection
  2. SARS-CoV
  3. TH1217

TH1217 (Synonyms: ZINC1775962367)

Cat. No.: HY-135909
Handling Instructions

TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19.

For research use only. We do not sell to patients.

TH1217 Chemical Structure

TH1217 Chemical Structure

CAS No. : 1862212-48-3

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Description

TH1217 (ZINC1775962367) is a potent and selective dCTPase pyrophosphatase 1 (dCTPase) inhibitor, with an IC50 of 47 nM. TH1217 enhances the cytotoxic effect of cytidine analogues in leukemia cells. TH1217 also could modulate SARS-Cov-2 interactors, so it shows activity of against COVID-19[1][2].

IC50 & Target

IC50: 47 nM (dCTPase)[1]

In Vitro

TH1217 (compound 30) inhibits dCTPase and enhances aqueous solubility (>100 μM) and improves plasma stability in vitro(t4h=86%)[1].
TH1217 presents suitable mouse microsomal half-lives (109 minutes)[1].
TH1217 displays well cell permeability (8.66×10-6/1.30×10-3 cm/s) and CYP inhibition[1].

Molecular Weight

491.09

Formula

C₂₀H₁₇BCl₂N₄O₆

CAS No.

1862212-48-3

SMILES

CC1=NC2=C(C(Cl)=C(Cl)C=C2N1CC3=CC=C(C=C3)[B-]45OC(C[N+]4(C)CC(O5)=O)=O)[N+]([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TH1217ZINC1775962367TH 1217TH-1217ZINC 1775962367ZINC-1775962367SARS-CoVSARS coronavirusdCTPasepyrophosphataseleukemiaSARS-Cov-2COVID-19Inhibitorinhibitorinhibit

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