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Cat. No.: HY-111483A

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Tizaterkib hexanedioic acid

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Tizaterkib hexanedioic acid (example 18) is a potent and selective ERK2 inhibitor, with an IC₅₀ of 0.6 nM.

For research use only. We do not sell to patients.

CAS No.: 2097416-93-6
Formula: C₂₄H₂₄F₂N₈O₂.1/2C₆H₁₀O₄
Molecular Weight:567.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Tizaterkib hexanedioic acid Chemical Structure

CAS No.: 2097416-93-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Tizaterkib hexanedioic acid (example 18) is a potent and selective ERK2 inhibitor, with an IC₅₀ of 0.6 nM^[1].

IC₅₀ & Target^[1]

ERK2

0.6 nM (IC₅₀)

All ERK Isoforms :

Chemical Information

CAS No. 2097416-93-6
Molecular Weight 567.57
Formula C₂₄H₂₄F₂N₈O₂.1/2C₆H₁₀O₄
SMILES

OC(CCCCC(O)=O)=O.O=C1C2=NC(C3=NC(NC4=CC=NN4C)=NC=C3C)=CN2C[C@@H](N1CC5=CC(F)=C(C=C5)F)COC.[1/2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Int J Mol Sci

ERK1/2 Inhibition via the Oral Administration of Tizaterkib Alleviates Noise-Induced Hearing Loss While Tempering down the Immune Response. [Abstract]

2024 Jun 7;25(12):6305. PMID: 38928015
Vet Microbiol

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) induces IL-6 production through TAK-1/JNK/AP-1 and TAK-1/NF-κB signaling pathways. [Abstract]

2021 May:256:109061. PMID: 33836390
bioRxiv

ERK1/2 Inhibition Alleviates Noise-Induced Hearing Loss While Tempering Down the Immune Response. [Abstract]

2023 Oct 20:2023.10.18.563007. PMID: 37905140

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. WARD, Richard, Andrew, et al. DIHYDROIMIDAZOPYRAZINONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER. WO2017080979A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Tizaterkib hexanedioic acid

3 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (3)
Purity & Documentation
References

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Tizaterkib hexanedioic acid

Publications Citing Use of MedChemExpress (MCE) Tizaterkib hexanedioic acid

All ERK Isoforms

Biological Activity

Chemical Information

Publications (3)

Purity & Documentation

References

Calculators

Help & FAQs

Tizaterkib hexanedioic acid Related Classifications

HY-111483A Related Classifications