1. Apoptosis
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  3. TJ191

TJ191 

Cat. No.: HY-120075 Purity: 99.83%
Handling Instructions

TJ191 is a potent and specific anti-cancer agent that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. TJ191 has no affects on the proliferation of other cancer cells or normal fibroblasts or immune cells. TJ191 can be used for cancer research.

For research use only. We do not sell to patients.

TJ191 Chemical Structure

TJ191 Chemical Structure

CAS No. : 1522415-97-9

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5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 130 In-stock
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25 mg USD 250 In-stock
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50 mg USD 400 In-stock
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100 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

TJ191 is a potent and specific anti-cancer agent that targets low TβRIII-expressing malignant T-cell leukemia/lymphoma cells. TJ191 has no affects on the proliferation of other cancer cells or normal fibroblasts or immune cells. TJ191 can be used for cancer research[1].

In Vitro

TJ191(0-100 µM; 24 hours) exhibits pronounced anti-proliferative activity in malignant cell lines, the IC50 values are 0.13 µM, 0.13±0.08 µM, 0.26±0.19 µM, 0.22±0.11 µM, 1.5±0.02 µM, 0.32±0.086 µM, 3.1±0.5 µM, 0.26±0.16 µM in CEM, JURKAT, MOLT-3, MOLT-4, SUP-T1, MT-2, C8166 and HSB-2 cells, respectively. But has no effects in HUT-78 (IC50=17±10 µM) and MT-4 (IC50=47 ± 5 µM) cells[1].
TJ191 (0.1-3 µM; 8 or 24 hours) induces CEM cell apoptosis in a concentration- and time-dependent manner. Even at 0.3 µM, TJ191 induces the maximum apoptotic rate of 80% after 24 h[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Malignant T-cell leukemia/lymphoma cells
Concentration: 0.01 µM, 0.1 µM, 1 µM, 10 µM, 100 µM
Incubation Time: 24 hours
Result: Exhibited inhibitory effects in drug-sensitive cells with IC50 ranging 0.13 µM to 3.1 µM.

Apoptosis Analysis[1]

Cell Line: CEM cell line
Concentration: 0.1-3 µM
Incubation Time: 8 or 24 hours
Result: Led to cell apoptosis.
Molecular Weight

255.38

Formula

C₁₃H₂₁NO₂S

CAS No.
SMILES

O=C(C1=C(N)SC(CCCCCCC)=C1)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

TJ191TJ 191TJ-191ApoptosisCEMJURKATMOLT-3MOLT-4SUP-T1MT-2C8166HSB-2apoptosiscancerPMBCInhibitorinhibitorinhibit

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