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Cat. No.: HY-184491

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TLX activator-1

TLX activator-1 is a highly selective TLX activator with an EC₅₀ of 0.010 μM. TLX activator-1 regulates gene expression, upregulates genes related to ATP production and lysosomal function, and inhibits genes associated with inflammatory signaling pathways and Apoptotic signaling pathways. TLX activator-1 exhibits anti-neurodegenerative activity. TLX activator-1 can be used for the research of neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 3108130-51-1
Formula: C₂₂H₁₈F₃N₃O₂S
Molecular Weight:445.46

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Please store the product under the recommended conditions in the Certificate of Analysis.

TLX activator-1 Chemical Structure

CAS No.: 3108130-51-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

TLX activator-1 (Compound 35) (16 h) activates the inhibitory function of TLX in HEK293T cells, with an EC₅₀ of 0.010 μM^[1].
At a concentration of 3 μM, TLX activator-1 exhibits a selectivity for TLX that is ≥30-fold higher than that for a panel of nuclear receptors in HEK293T cells, and its IC₅₀ for the inverse agonism of RORα is 8 μM^[1].
TLX activator-1 (10 μM; 0-120 min) exhibits high metabolic stability in liver microsomes, with a half-life of 113 min^[1].
TLX activator-1 (1 μM; 16 h) exerts anti-neurodegenerative effects by regulating the transcriptome of ARPE-19 cells, which involves upregulating genes related to ATP production, lysosomal function and mitochondrial quality control, while downregulating genes associated with inflammation, apoptosis and amyloidogenic pathways^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3108130-51-1
Molecular Weight 445.46
Formula C₂₂H₁₈F₃N₃O₂S
SMILES

CN(C=C1)C2=C1C=C(C3=CC(C(F)(F)F)=CC(NS(CC4=CC=CC=C4)(=O)=O)=C3)C=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hank EC, et al. An Activator of Tailless' Repressor Function Stimulates Anti-Neurodegenerative Gene Expression. Journal of medicinal chemistry. 2026 Jun 25;69(12):14704-14721. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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