2. Epigenetics
  3. HuR
  4. TM11

TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages.

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TM11

TM11 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg In-stock
25 mg In-stock
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TM11 Related Antibodies

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Description

TM11, a Tanshinone mimic, is a potent HuR inhibitor that can inhibit HuR-RNA complex formation. TM11 reduces LPS-induced inflammatory response in murine macrophages[1].

Molecular Weight

353.35

Formula

C18H11NO5S
Appearance

Solid

Color

Dark purple to black

SMILES

O=C1C2=C(N(S(=O)(C3=CC=CC=C3)=O)C=C2C4=CC=CO4)C=CC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (141.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8301 mL 14.1503 mL 28.3006 mL
5 mM 0.5660 mL 2.8301 mL 5.6601 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8301 mL 14.1503 mL 28.3006 mL 70.7514 mL
5 mM 0.5660 mL 2.8301 mL 5.6601 mL 14.1503 mL
10 mM 0.2830 mL 1.4150 mL 2.8301 mL 7.0751 mL
15 mM 0.1887 mL 0.9434 mL 1.8867 mL 4.7168 mL
20 mM 0.1415 mL 0.7075 mL 1.4150 mL 3.5376 mL
25 mM 0.1132 mL 0.5660 mL 1.1320 mL 2.8301 mL
30 mM 0.0943 mL 0.4717 mL 0.9434 mL 2.3584 mL
40 mM 0.0708 mL 0.3538 mL 0.7075 mL 1.7688 mL
50 mM 0.0566 mL 0.2830 mL 0.5660 mL 1.4150 mL
60 mM 0.0472 mL 0.2358 mL 0.4717 mL 1.1792 mL
80 mM 0.0354 mL 0.1769 mL 0.3538 mL 0.8844 mL
100 mM 0.0283 mL 0.1415 mL 0.2830 mL 0.7075 mL
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TM11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TM11TM 11TM-11HuRHuman Antigen RHuR-RNA complexLPSmacrophagesInhibitorinhibitorinhibit

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