2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. TM6008

TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008  exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research.

For research use only. We do not sell to patients.

TM6008 Chemical Structure

TM6008 Chemical Structure

CAS No. : 945008-17-3

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Description

TM6008 is a potent and orally active prolyl hydroxylase (PHD) inhibitor. TM6008 chelats transition metal (copper) and inhibits the autoxidation of ascorbic acid with an IC50 value is 0.57 μM. TM6008  exerts organ protection against ischemia in vivo and can be used for cerebrovascular disease research[1].

In Vivo

TM6008 (p.o.; 50 mg/kg; single dosage) exhibits plasma Tmax, Cmax, and T1/2 values of 3.5 hour, 0.9 μg/mL and 1.5 hour for TM6008 in rat[1].
TM6008 (p.o.; 100 mg/kg; 7 days) protects against hypoxia-induced apoptotic neuronal death and decreases the number of apoptotic cells in Gerbils after a 5-minute transient global cerebral ischemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Gerbils after a 5-minute transient global cerebral ischemia[1]
Dosage: 100 mg/kg
Administration: p.o.; 100 mg/kg; 7 days
Result: Exerted organ protection against ischemia in vivo.
Molecular Weight

387.39

Formula

C21H17N5O3
CAS No.
SMILES

O=C1N(C)C(C(C(C2=CC(C3=NC=CC=C3)=NC4=CC=CC=C24)=O)=C(N)N1C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TM6008 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TM6008945008-17-3TM 6008TM-6008HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHHypoxia inducible factorHIFischemiccerebrovascular diseaseangiogenesisInhibitorinhibitorinhibit

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