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Cat. No.: HY-151150

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Trypanothione synthetase-IN-2

Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC₅₀ of 5.4 μM when triamine spermidine is as polyamine S.

For research use only. We do not sell to patients.

CAS No.: 3033799-60-6
Formula: C₄₁H₆₉N₇O₁₁
Molecular Weight:836.03

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Trypanothione synthetase-IN-2 Chemical Structure

CAS No.: 3033799-60-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Leishmania

All Parasite Isoforms :

In Vitro

Trypanothione synthetase-IN-2 (Compound 3) (0-75 μM; 24 or 72 h) shows leishmanicidal activity without cytotoxicity^[1].
Trypanothione synthetase-IN-2 displays a classical competitive mechanism of inhibition against the polyamine substrates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

L. infantum, HepG2
Concentration:

0-75 μM
Incubation Time:

24 h (L. infantum axenic amastigotes) or 72 h
Result:

Showed leishmanicidal activity with EC₅₀s of 7.3 ± 0.5 μM and 17.9 ± 0.4 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC₅₀ of >75 μM against HepG2 cells.

Chemical Information

CAS No. 3033799-60-6
Molecular Weight 836.03
Formula C₄₁H₆₉N₇O₁₁
SMILES

O=C(C1=CC(OCCN)=C(C(OCCN)=C1)OCCN)OCC(COC(C2=CC(OCCN)=C(C(OCCN)=C2)OCCN)=O)NC(CCCCCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Alcón-Calderón M, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022: 114675.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Trypanothione synthetase-IN-2

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Trypanothione synthetase-IN-2 Related Classifications

HY-151150 Related Classifications