Trypanothione synthetase-IN-2
Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 5.4 μM when triamine spermidine is as polyamine S.
For research use only. We do not sell to patients.
- CAS No.: 3033799-60-6
- Formula: C41H69N7O11
- Molecular Weight:836.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
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Leishmania |
In Vitro
Trypanothione synthetase-IN-2 (Compound 3) (0-75 μM; 24 or 72 h) shows leishmanicidal activity without cytotoxicity[1].
Trypanothione synthetase-IN-2 displays a classical competitive mechanism of inhibition against the polyamine substrates[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:L. infantum, HepG2
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Concentration:0-75 μM
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Incubation Time:24 h (L. infantum axenic amastigotes) or 72 h
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Result:Showed leishmanicidal activity with EC50s of 7.3 ± 0.5 μM and 17.9 ± 0.4 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of >75 μM against HepG2 cells.
Chemical Information
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CAS No. 3033799-60-6
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Molecular Weight 836.03
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Formula C41H69N7O11
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SMILES
O=C(C1=CC(OCCN)=C(C(OCCN)=C1)OCCN)OCC(COC(C2=CC(OCCN)=C(C(OCCN)=C2)OCCN)=O)NC(CCCCCCCCCCC)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trypanothione synthetase-IN-2 Related Classifications
HY-151150 Related Classifications
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