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Cat. No.: HY-149069

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TSC25

TSC25 is a potent cruzipain (CZP) inhibitor, with an IC₅₀ of 3.34 nM and a pIC₅₀ of 8.48.

For research use only. We do not sell to patients.

Formula: C₁₄H₁₈Cl₂N₄OS
Molecular Weight:361.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

TSC25 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

TSC25 is a potent cruzipain (CZP) inhibitor, with an IC₅₀ of 3.34 nM and a pIC₅₀ of 8.48^[1].

All Cathepsin Isoforms :

Chemical Information

Molecular Weight 361.29
Formula C₁₄H₁₈Cl₂N₄OS
SMILES

NC(N/N=C(C1=CC=C(C(Cl)=C1)Cl)\CCN2CCOCC2)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jasinski G, et al. Design, synthesis and biological evaluation of novel thiosemicarbazones as cruzipain inhibitors. Eur J Med Chem. 2023 Apr 7;254:115345. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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