AMD1 - adenosylmethionine decarboxylase 1 Gene

Also Known as AMD; SAMDC; ADOMETDC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 262

About AMD1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,814,617-110,895,713 (from NCBI)

This gene has 10 transcripts (splice variants) and 256 orthologues. Ubiquitous expression in prostate (RPKM 106.1), bone marrow (RPKM 38.6) and 25 other tissues.

Summary

This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Multiple alternatively spliced transcript variants have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. [provided by RefSeq, Dec 2013]

AMD1 Products (7)

mRNA	Protein	Name
NM_001287214.1	NP_001274143.1	S-adenosylmethionine decarboxylase proenzyme isoform 3
NM_001287215.2	NP_001274144.1	S-adenosylmethionine decarboxylase proenzyme isoform 4
NM_001287216.1	NP_001274145.1	S-adenosylmethionine decarboxylase proenzyme isoform 5
NM_001393406.1	NP_001380335.1	S-adenosylmethionine decarboxylase proenzyme isoform 4
NM_001393407.1	NP_001380336.1	S-adenosylmethionine decarboxylase proenzyme isoform 6
NM_001393408.1	NP_001380337.1	S-adenosylmethionine decarboxylase proenzyme isoform 6
NM_001634.6	NP_001625.2	S-adenosylmethionine decarboxylase proenzyme isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMD1 Protein Structure

SAM_decarbox

0
100
200
300
334 a.a.

Protein Preferred Names	Protein Names
S-adenosylmethionine decarboxylase proenzyme	S-adenosylmethionine decarboxylase 1

AMD1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AMD1	P17707	AMD1	Homo sapiens	P17707	Validated Y2H	32296183
Intra	AMD1	P17707	AMD1	Homo sapiens	P17707	Y2H Prey Pooling	32296183
Intra	AMD1	P17707	AMD1	Homo sapiens	P17707	Y2H Array	32296183
Intra	AMD1	P17707	THAP4	Homo sapiens	Q8WY91	Validated Y2H	32296183
Intra	AMD1	P17707	THAP4	Homo sapiens	Q8WY91	Y2H Prey Pooling	32296183
Intra	AMD1	P17707	THAP4	Homo sapiens	Q8WY91	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

AMD1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810846	AMD1 Antibody	WB, ICC/IF	Human, Mouse, Rat, Bovine

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 87	DEE87 Epileptic Encephalopathy, Early Infantile, 87 Eiee87 Developmental And Epileptic Encephalopathy, 87 Early Infantile Epileptic Encephalopathy 87
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Trypanosomiasis
Chagas Disease	American Trypanosomiasis Chagas' Disease Chagas' Disease With Digestive System Involvement Chagas' Disease With Nervous System Involvement Chagas' Disease With Other Organ Involvement Infection Due To Trypanosoma Cruzi South American Trypanosomiasis Chronic Chagas Disease With Digestive System Involvement
Syndromic X-Linked Intellectual Disability Snyder Type	Snyder-Robinson Syndrome Mental Retardation, X-Linked, Snyder-Robinson Type Spermine Synthase Deficiency Srs Snyder-Robinson Mental Retardation Syndrome X-Linked Intellectual Disability Snyder-Robinson Type Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type Snyder-Robinson X-Linked Mental Retardation Syndrome
Secondary Progressive Multiple Sclerosis	Secondary-Progressive Ms Spms Multiple Sclerosis, Chronic Progressive Chronic Progressive Multiple Sclerosis Multiple Sclerosis, Secondary Progressive
Transient Cerebral Ischemia	Transient Ischemic Attack Transient Ischemic Attacks Tia Tia - Transient Ischaemic Attack Transient Cerebral Ischaemia Ischemic Attack, Transient Intermittent Cerebral Ischemia Tia - [Transient Ischaemic Attack] Intermittent Cerebral Ischaemia Transient Cerebral Ischaemic Attack, Unspecified, Course Of Resolution Unspecified
Retinitis Pigmentosa 61	RP61 Retinitis Pigmentosa, Type 61
Mitochondrial Complex Iv Deficiency, Nuclear Type 1	Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency Cox Deficiency Cytochrome-C Oxidase Deficiency Disease MC1DN4 Cytochrome-C Oxidase Deficiency MC4DN1 Mitochondrial Complex I Deficiency, Nuclear Type 4 Complex 4 Mitochondrial Respiratory Chain Deficiency Complex Iv Deficiency Mitochondrial Complex 1 Deficiency, Nuclear Type 4 Nuclear Type Mitochondrial Complex I Deficiency 4 Deficiency Of Mitochondrial Respiratory Chain Complex4 MT-C4D Complex Iv Mitochondrial Respiratory Chain Deficiency Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency, Nuclear, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109561	Pegaptanib sodium	Inhibitor	90.51%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P3252A	Pegcetacoplan acetate	Inhibitor	99.92%	Phase 3
HY-19720A	Emixustat hydrochloride	Inhibitor	99.29%	Phase 3
HY-N0679S	Retinyl acetate-d3		/	Phase 3
HY-15492	AG-13958	Inhibitor	99.69%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99629	Galegenimab	Inhibitor	99.91%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19720	Emixustat		98.00%	Yes
HY-132126	SPHINX	Inhibitor	99.87%	Unkown
HY-RS09498	NPR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-15492A	AG-13958 (mono(hydrochloride))	Inhibitor	/	Unkown
HY-RS00644	AMD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W888515	mPEG-PCL		/	Unkown
HY-RS18124	Amd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24598	Amd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AMD1	VGNC	VGNC:37827
Macaca mulatta	AMD1	VGNC	VGNC:81021
Bos taurus	AMD1	VGNC	VGNC:25859
Mus musculus	AMD1	MGD	MGI:88004
Rattus norvegicus	AMD1	RGD	RGD:2104
Others	AMD1	NCBI