Luffariellolide
Luffariellolide is an inhibitor of human synovial fluid phospholipase A2 (HSF-PLA2) (IC50=5 μM). Luffariellolide effectively inhibits phorbol ester (PMA)-induced ear edema (ED50=50 μg/ear).
For research use only. We do not sell to patients.
- CAS No.: 111149-87-2
- Formula: C25H38O3
- Molecular Weight:386.57
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Phospholipase Isoforms
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| L5178Y | ED50 |
3.3 μg/mL
Compound: 6
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Cytotoxicity against mouse L5178Y cells by MTT assay
Cytotoxicity against mouse L5178Y cells by MTT assay
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[PMID: 15568767] |
| MDA-MB-231 | IC50 |
4.5 μM
Compound: 11
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Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by SRB assay
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[PMID: 23944963] |
| T47D | IC50 |
3.6 μM
Compound: 11
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Inhibition of hypoxia-induced HIF-1 activation in human T47D cells by luciferase reporter gene assay
Inhibition of hypoxia-induced HIF-1 activation in human T47D cells by luciferase reporter gene assay
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[PMID: 23944963] |
| T47D | IC50 |
5.1 μM
Compound: 11
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Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
Antiproliferative activity against human T47D cells after 48 hrs by SRB assay
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[PMID: 23944963] |
Chemical Information
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CAS No. 111149-87-2
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Appearance Oil
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Molecular Weight 386.57
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Formula C25H38O3
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Color Off-white to light yellow
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SMILES
CC1(CCCC(C)=C1CC/C(C)=C/CC/C(C)=C/CCC2=CC(OC2O)=O)C
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Structure Classification
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Initial Source
Palauan sponge
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (263 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Luffariellolide Related Classifications
HY-118725 Related Classifications
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