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Cat. No.: HY-187602

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U-26384

U-26384 is a Phospholipase A₂ inhibitor. U-26384 reduces Sodium iodoacetate (HY-D0849)-induced Arachidonic acid (HY-109590) release and cell damage. U-26384 can be used for research on Graves' disease and ischemic brain injury.

For research use only. We do not sell to patients.

CAS No.: 112646-88-5
Formula: C₂₅H₄₂N₂O
Molecular Weight:386.61

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

U-26384 Chemical Structure

CAS No.: 112646-88-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Phospholipase Isoforms :

In Vitro

U-26384 (5 μM) does not significantly inhibit IgG-induced Arachidonic acid (HY-109590) release in FRTL-5 thyroid cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 112646-88-5
Molecular Weight 386.61
Formula C₂₅H₄₂N₂O
SMILES

C[C@@]12[C@](CC[C@@H]2N(C)CCCN(C)C)([H])[C@@]3([H])[C@@](CC1)([H])C4=C(CC(OC)=CC4)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Atwa MA, et al. Immunoglobulins from Graves' disease patients stimulate phospholipase A2 and C systems in FRTL-5 and human thyroid cells. European journal of endocrinology. 1996 Sep;135(3):322-7.

[2]. Sun FF, et al. Degradation of membrane phospholipids in the cultured human astroglial cell line UC-11MG during ATP depletion. Biochemical pharmacology. 1993 Mar 09;45(5):1149-55.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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