2. Cell Cycle/DNA Damage Epigenetics Autophagy
  3. Sirtuin Autophagy
  4. UBCS039

UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM.

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CAS 番号 : 358721-70-7

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 165 在庫あり
Solution
10 mM * 1 mL in DMSO USD 165 在庫あり
Solid
5 mg $150 在庫あり
10 mg $240 在庫あり
25 mg $480 在庫あり
50 mg $690 在庫あり
100 mg $980 在庫あり
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カスタマーレビュー

Based on 17 publication(s) in Google Scholar

UBCS039 関連抗体

Top Publications Citing Use of Products

    UBCS039 purchased from MedChemExpress. Usage Cited in: PLoS Pathog. 2023 Apr 6;19(4):e1011324.  [Abstract]

    UBCS039 (80 μM; 24 h) enhances the expression of SIRT6 in iSLK-RGB and THP-1cells.

    Sirtuin アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7 SIRT4

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

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    製品説明

    UBCS039 is the first synthetic, specific Sirtuin 6 (SIRT6) activator, inducing autophagy in human tumor cells, with an EC50 of 38 μM[1].

    IC50 & Target[1]

    SIRT6

    38 μM (EC50)

    体外実験

    UBCS039 (75 μM, 48 or 72 hours) induces deacetylation of SIRT6-targeted histone H3 sites in human cancer cells[2].
    UBCS039 leads to autophagosome accumulation in human cancer cells[2].
    UBCS039 induces autophagy via AMP-activated protein kinase (AMPK) signaling pathway activation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    UBCS039 関連抗体

    Western Blot Analysis[2]

    Cell Line: Human H1299 cells.
    Concentration: 75 μM.
    Incubation Time: 48 and 72 hours.
    Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

    Western Blot Analysis[2]

    Cell Line: Human H1299 cells.
    Concentration: 75 μM.
    Incubation Time: 48 and 72 hours.
    Result: Induced deacetylation of SIRT6-targeted histone H3 sites in human H1299 cells.

    Cell Proliferation Assay[2]

    Cell Line: Human H1299 cells.
    Concentration: 100 μM.
    Incubation Time: 48 and 72 hours.
    Result: Led to a strong decrease of cell proliferation in a dose-dependent manner when compared with control or DMSO-treated cells, starting from day 3 of growth (48 h after treatment) in both H1299 and HeLa cell lines.
    分子量

    247.29

    分子式

    C16H13N3
    CAS 番号
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    N12C(C(C3=CC=CN=C3)NC4=C2C=CC=C4)=CC=C1
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (404.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 4.0438 mL 20.2192 mL 40.4384 mL
    5 mM 0.8088 mL 4.0438 mL 8.0877 mL
    10 mM 0.4044 mL 2.0219 mL 4.0438 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    一般には略語で表示されます：C1V1 = C2V2

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    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (8.41 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (8.41 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
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    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 98.88%

    COA (253 KB) HNMR (246 KB) LCMS (95 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 4.0438 mL 20.2192 mL 40.4384 mL 101.0959 mL
    5 mM 0.8088 mL 4.0438 mL 8.0877 mL 20.2192 mL
    10 mM 0.4044 mL 2.0219 mL 4.0438 mL 10.1096 mL
    15 mM 0.2696 mL 1.3479 mL 2.6959 mL 6.7397 mL
    20 mM 0.2022 mL 1.0110 mL 2.0219 mL 5.0548 mL
    25 mM 0.1618 mL 0.8088 mL 1.6175 mL 4.0438 mL
    30 mM 0.1348 mL 0.6740 mL 1.3479 mL 3.3699 mL
    40 mM 0.1011 mL 0.5055 mL 1.0110 mL 2.5274 mL
    50 mM 0.0809 mL 0.4044 mL 0.8088 mL 2.0219 mL
    60 mM 0.0674 mL 0.3370 mL 0.6740 mL 1.6849 mL
    80 mM 0.0505 mL 0.2527 mL 0.5055 mL 1.2637 mL
    100 mM 0.0404 mL 0.2022 mL 0.4044 mL 1.0110 mL
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    UBCS039 Related Classifications

    • Molarity Calculator

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    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    UBCS039358721-70-7UBCS 039UBCS-039SirtuinAutophagyInhibitorinhibitorinhibit

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    製品名:
    UBCS039
    製品番号:
    HY-115453
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