country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-125790

Copy Link Print Information

Cyclazocine

Cyclazocine is a μ, δ, and κ opioid receptor modulator with K_i values of 0.32, 1.1, and 0.18 nM, respectively. Cyclazocine exhibits "mixed" pharmacological activities, acting as a μ-partial antagonist, κ-agonist, and low-affinity δ ligand. Cyclazocine shows antinociceptive activity in mice. Cyclazocine can be used in studies on psychoactive substance addiction.

For research use only. We do not sell to patients.

CAS No.: 3572-80-3
Formula: C₁₈H₂₅NO
Molecular Weight:271.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Cyclazocine Chemical Structure

CAS No.: 3572-80-3

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

μ Opioid Receptor/MOR

0.32 nM (Ki)

κ Opioid Receptor/KOR

1.1 nM (Ki)

δ Opioid Receptor/DOR

0.18 nM (Ki)

All Opioid Receptor Isoforms :

In Vitro

Cyclazocine potently binds to μ, δ, and κ opioid receptors in guinea pig brain cell membranes, with K_i values of 0.32 nM, 1.1 nM, and 0.18 nM, respectively^[1].
Cyclazocine potently binds to the human μ-opioid receptor stably expressed in CHO cells, with a K_i value of 0.16 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

Cyclazocine (1 mg/kg; i.p.; single dose) administered in mice exhibits antinociceptive activity with a 2-hour duration of action^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3572-80-3
Molecular Weight 271.40
Formula C₁₈H₂₅NO
SMILES

OC1=CC=C2C(C3(CCN(C(C3C)C2)CC4CC4)C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wentland MP, et al. Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine. Bioorg Med Chem Lett. 2005;15(10):2547-2551. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote