Etokimab
Based on 1 Customer Validation
Etokimab (Antibody ANB 020) is a humanized monoclonal antibody that targets IL-33. Etokimab can be used for the research of atopic dermatitis.
For research use only. We do not sell to patients.
- Purity : 99.00%
- CAS No.: 2022981-44-6
- Molecular Weight:146.56 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
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IL-3 |
In Vitro
Etokimab (5 μg/mL, 1 h) inhibits IL-33 induced neutrophil migration, suppresses IL-33-induced CXCR1 expression in human peripheral blood neutrophils[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human peripheral blood neutrophils
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Concentration:5 μg/mL
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Incubation Time:1 h
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Result:Inhibited the cell migration.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1.5×106 HUVEC cells labeling Etokimab (HY-P99018, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black). -
Loaded Etokimab on AHC2 biosensor, can bind IL-33 Protein, Human (His, HY-P70475) with an affinity constant of 8.643E-11 M as determined in BLI assay.
Chemical Information
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CAS No. 2022981-44-6
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Appearance Liquid
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Molecular Weight 146.56 kDa
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Color Colorless to light yellow
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SMILES
[Etokimab]
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Synonyms
Antibody ANB 020
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)