CEACAM3 - CEA cell adhesion molecule 3 Gene

Also Known as CEA; CGM1; W264; W282; CD66D

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1084

About CEACAM3

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,796,587-41,811,554 (from NCBI)

This gene has 8 transcripts (splice variants), 559 orthologues, 24 paralogues and is associated with 1 phenotype. Biased expression in bone marrow (RPKM 11.7), appendix (RPKM 5.0) and 3 other tissues.

Summary

This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several Bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several Bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

CEACAM3 Products (2)

mRNA	Protein	Name
NM_001277163.3	NP_001264092.1	carcinoembryonic antigen-related cell adhesion molecule 3 isoform 2 precursor
NM_001815.5	NP_001806.2	carcinoembryonic antigen-related cell adhesion molecule 3 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27442026	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEACAM3 Protein Structure

V-set

0
100
200
252 a.a.

Protein Preferred Names	Protein Names
carcinoembryonic antigen-related cell adhesion molecule 3	CD66d antigen

CEACAM3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CEACAM3	P40198	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	CEACAM3	P40198	CNIH3	Homo sapiens	Q8TBE1	Validated Y2H	32296183
Cross	CEACAM3	P40198	opaH	Neisseria gonorrhoeae	Q04884	FPS	27442026
Cross	CEACAM3	P40198	opaD	Neisseria gonorrhoeae	Q04883	FPS	27442026
Intra	CEACAM3	P40198	NINJ1	Homo sapiens	Q92982	Validated Y2H	32296183
Intra	CEACAM3	P40198	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEACAM3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72130	CEACAM3 Protein, Human (His-SUMO)	P40198 (K35-G155)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72694	CEACAM3 Protein, Human (HEK293, His)	P40198 (K35-G155)	≥ 95%, as determined by reducing SDS-PAGE.

CEACAM3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84294	CEACAM3 Antibody (YA3991)	WB, FC, ELISA	Human, Rat
HY-P84294A	CEACAM3 Antibody (YA3991)(PBS only)	WB, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Mucinous Cystadenocarcinoma	Cystadenocarcinoma, Mucinous Pseudomucinous Cystadenocarcinoma Cystadenocarcinoma Mucinous
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Chronic Gonococcal Salpingitis	Gonococcal Salpingitis
Acute Salpingitis
Thymic Carcinoma	Malignant Thymoma Thymoma, Malignant
Cystadenocarcinoma
Pulmonary Alveolar Proteinosis
Bile Duct Adenoma	Cholangioadenoma Adenoma Bile Duct Adenoma, Bile Duct
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Chordoma	CHDM Notochordoma Notochordal Sarcoma Chordoma, Susceptibility To Chordocarcinoma Chordoepithelioma
Cystadenoma	Cystoma Craniopharyngioma
Carcinosarcoma	Mixed Tumor, Mullerian Malignant Mixed Mesodermal Tumor Malignant Mixed Mullerian Tumor Mmmt Mixed Tumor, Mesodermal Mesodermal Mixed Tumor Mixed Mesodermal Tumor Mullerian Mixed Tumor Mixed Mullerian Tumor Malignant Mixed Müllerian Tumor Mixed Müllerian Tumor Mixed Tumor Mullerian Mixed Tumor, Not Otherwise Specified
Mesothelioma, Malignant	Malignant Mesothelioma Pleural Mesothelioma MESOM Mesothelioma, Somatic Advanced Malignant Mesothelioma Asbestos-Related Malignant Mesothelioma Diffuse Malignant Mesothelioma Malignant Tumor Of Mesothelium Malignant Mesothelioma, Susceptibility To Mesothelioma Diffuse Malignant Mesothelioma Malignant Pleural Mesothelioma
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Myxedema
Chronic Salpingitis
Paget Disease, Extramammary	Extramammary Paget Disease Cutaneous Paget'S Disease Extramammary Paget'S Disease Paget Disease Extramammary Cutaneous Paget Disease Paget'S Disease Of Skin Empd Extramammary Pagets Disease
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Fallopian Tube Disease	Fallopian Tube Diseases
Ophthalmia Neonatorum	Gonococcal Conjunctivitis Gonococcal Ophthalmia Neonatorum Neonatal Conjunctivitis
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Polycystic Liver Disease 1 PCLD1 Cyst Liver Disease, Polycystic, Type 1 Polycystic Liver Disease
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Sertoli-Leydig Cell Tumor	Sertoli-Leydig Cell Tumors Androblastoma Of Ovary Arrhenoblastoma Arrhenoblastoma Of Ovary Sertoli-Leydig Cell Tumor Of The Ovary Sertoli-Leydig Cell Tumor Of Intermediate Differentiation Sertoli-Leydig Cell Tumor Of Ovary
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Adenoid Cystic Carcinoma	Adenocystic Carcinoma Cribriform Carcinoma Cylindroma Carcinoma Adenoid Cystic Carcinoma, Adenoid Cystic Adenoid Cystic Carcinoma Of Salivary Gland Eccrine Dermal Cylindroma Carcinoma, Cribriform
Bacterial Conjunctivitis	Purulent Conjunctivitis Conjunctivitis, Bacterial
Cheilitis
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Gastrointestinal Carcinoma	Gastrointestinal Neoplasms
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Rectum Cancer	Malignant Neoplasm Of Rectum Rectal Cancer Cancer Of Rectum Carcinoma Of Rectum Carcinoma Of The Rectum Malignant Rectal Tumor Malignant Rectum Tumor Malignant Tumor Of Rectum Rectal Carcinoma Rectal Cancers Cancer, Rectal
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02438	CEACAM21 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02439	CEACAM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990854	Anti-CEACAM1/3/5/6/8 Antibody (6G5j)	Inhibitor	/	Unkown