BMP3 - bone morphogenetic protein 3 Gene

Also Known as BMP-3A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 651

About BMP3

Cytogenetic location: 4q21.21 Genomic coordinates (GRCh38): 4:81,030,708-81,057,627 (from NCBI)

This gene has 1 transcript (splice variant), 200 orthologues and 31 paralogues. Biased expression in urinary bladder (RPKM 12.1), colon (RPKM 5.2) and 5 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta Receptor availability to Other ligands. [provided by RefSeq, Jul 2016]

BMP3 Products (1)

mRNA Protein Name
NM_001201.5 NP_001192.4 bone morphogenetic protein 3 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables BMP receptor binding IDA
IDA: Inferred from direct assay
7811286 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BMP3 Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (52 - 214)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (368 - 472)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein 3

  • bone morphogenetic protein 3 (osteogenic)

Recombinant BMP3 Proteins

Cat. No. Product Name Accession Purity
HY-P79077 BMP-3 Protein, Human P12645 (Q363-R472) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700026AF Animal-Free BMP-3 Protein, Human (His) P12645 (Q363-R472) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Brachydactyly, Type A2

  • Brachydactyly Type A2

  • BDA2

  • Mohr-Wriedt Type Brachydactyly

  • Brachymesophalangy Ii

  • Brachymesophalangy Type 2

  • Brachymesophalangy 2

  • Brachydactyly, Mohr-Wriedt Type

  • Brachydactyly A2
Myopia

  • Near-Sightedness

  • Short-Sightedness

  • Nearsightedness

  • Nearsighted

  • Near Vision

  • Close Sighted

  • Myopic

  • Short-Sighted

  • Near Sighted
Osteogenic Sarcoma

  • Osteosarcoma

  • OSRC

  • Osteosarcoma, Somatic

  • Neoplasms, Bone Tissue

  • Bone Tissue Neoplasm

  • Osteoid Sarcoma

  • Skeletal Sarcoma

  • Osteosarcoma Of Bone

  • Bone Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01538 BMP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20696 Bmp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27207 Bmp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BMP3 VGNC VGNC:26518
Rattus norvegicus BMP3 RGD RGD:2212
Mus musculus BMP3 MGD MGI:88179
Canis familiaris BMP3 VGNC VGNC:57398
Macaca mulatta BMP3 VGNC VGNC:70262
Felis catus BMP3 VGNC VGNC:60132
Others BMP3 NCBI