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Cat. No.: HY-D2317

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HaloFlipper 30

HaloFlipper 30 is a fluorescent HaloTag fusion protein probe. HaloFlipper 30 reacts with aspartate residues via a terminal chloroalkane to form an ester bond, achieving covalent attachment and membrane insertion; its ethylene glycol linker allows cell penetration, and genetic engineering of the HaloTag fusion protein enables intracellular targeting and labeling of membranes such as the ER, Golgi, and cytoplasm. HaloFlipper 30 enables mechanosensitive membrane tension imaging through planarization of a twisted push-pull mechanoresponsive group in the ground state.

For research use only. We do not sell to patients.

Formula: C₇₀H₁₀₆ClN₅O₂₂S₆
Molecular Weight:1597.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

HaloFlipper 30 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

HaloFlipper 30 covalently labels HaloTag fusion proteins in the ER, Golgi and cytosol of engineered cells and reports membrane tension changes as reproducible FLIM lifetime changes, with higher absolute lifetimes in Golgi than in ER^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1597.45
Formula C₇₀H₁₀₆ClN₅O₂₂S₆
SMILES

CC1=C(C#N)SC(C2=C3C(C)=C(C4=C(C)C(SC5=C6SC(COCC7=CN(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(NCCOCCOCCCCCCCl)=O)N=N7)=C5C)=C6S4)S2)=C1S3(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen XX, et al. Fluorescent Flippers: Small-Molecule Probes to Image Membrane Tension in Living Systems. Angewandte Chemie (International ed. in English). 2023 May 08;62(20):e202217868. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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