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Cat. No.: HY-P12370

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LTHVVWL

LTHVVWL is a Kim-1-binding peptide. LTHVVWL functionalizes extracellular vesicles and exosomes to achieve targeted delivery to injured renal tubules. LTHVVWL modifies FRC-Exos to enhance specificity for injured renal tubules. LTHVVWL functionalizes nanoparticles for active targeting of injured kidneys. LTHVVWL is grafted onto mesoporous silica nanoparticles via a PEG linker to seal the outer layer and prevent leakage. LTHVVWL acts as a calcium chelator through hydrolysis, generating active BAPTA and reducing intracellular Ca²⁺ overload. LTHVVWL can be used for acute kidney injury research.

For research use only. We do not sell to patients.

Formula: C₄₃H₆₆N₁₀O₉
Molecular Weight:867.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LTHVVWL Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

LTHVVWL is the preferred candidate for Kim-1 targeting due to its high binding affinity at low concentrations^[1].
LTHVVWL (5 μM; 6 h) specifically recognizes TEC overexpressing Kim-1 in vitro^[1].
LTHVVWL-anchored FRC-Exos are taken up by primary renal tubular cells in vitro, and fluorescence is observed under a confocal microscope after 24 hours of incubation, confirming this^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 867.05
Formula C₄₃H₆₆N₁₀O₉
SMILES

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CNC=N1)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Sequence

Leu-Thr-His-Val-Val-Trp-Leu
Sequence Shortening

LTHVVWL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tang TT, et al. Kim-1 Targeted Extracellular Vesicles: A New Therapeutic Platform for RNAi to Treat AKI. Journal of the American Society of Nephrology : JASN. 2021 Oct;32(10):2467-2483.

[2]. Li Y, et al. Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury. Kidney international. 2024 Mar;105(3):508-523.

[3]. Yan J, et al. Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment-Responsive BAPTA-AM/BAC Co-Delivery Nanosystem. Small (Weinheim an der Bergstrasse, Germany). 2023 Apr;19(17):e2206936.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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