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Cat. No.: HY-N12958

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Uvarialeptone C

Uvarialeptone C (compound 3) is a NO production inhibitor (IC₅₀: 6.7 μM). Uvarialeptone C can be isolated from the extract of Cladosporium purpurogenum.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₄O₇
Molecular Weight:436.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (298 KB)

Uvarialeptone C Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Uvarialeptone C (compound 3) is a NO production inhibitor (IC₅₀: 6.7 μM). Uvarialeptone C can be isolated from the extract of Cladosporium purpurogenum^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	6.7 μM Compound: 3	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 24 hrs by Griess reagent based analysis	[PMID: 38805684]
SNU1	IC₅₀	34 μM Compound: 3	Cytotoxicity against human SNU1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SNU1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38805684]

Chemical Information

Molecular Weight 436.45
Formula C₂₅H₂₄O₇
SMILES

O=C(/C1=C(O)\C=C\C2=CC=CC=C2)[C@](CC3=CC(OC)=CC=C3O4)(OC)[C@]4(OC)CC1=O
Initial Source
- Microorganisms
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (298 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Teerapongpisan P, Monkantha T, Yimklan S, Mah SH, Gunter NV, Promnart P, Deachathai S, Maneerat T, Duangyod T, Charoensup R, Baka A, Andersen RJ, Laphookhieo S. Tetrahydroxanthene-1,3(2H)-diones and Oxidized Hexadiene Derivatives from Uvaria leptopoda and Their Biological Activities. J Nat Prod. 2024 May 28.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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