Valerosidate 

Valerosidate is a Iridoids product that can be isolated from the herbs of Valeriana jatamansi. Valerosidate exhibites inhibitory effects on cell viability and migration in HCT116 cells via increasing the expressions of tumor suppressors (p53 and PTEN) Valerosidate is a natural orexin 2 receptor antagonist and can be used for the study of insomnia.

462.49

C₂₁H₃₄O₁₁

29505-31-5

Solid

White to off-white

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OCC2=CO[C@@H](OC(CC(C)C)=O)[C@@]3([H])[C@]2([H])C[C@H](O)[C@]3(O)C

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Yang H, Zheng T, Ku CF, et al. Discovery of a heat-generated compound DHD derived from Patrinia villosa water extract with inhibitory effects on colon cancer cells viability and migration. Front Chem. 2023;11:1195883.  [Content Brief]

  [2]. Shenoy AG, Ravi V, Subair S, Varman DR, Raju R, Rehman N. Discovery of natural orexin 2 receptor antagonists from Valeriana species: A potential approach for insomnia treatment. Chronobiol Int. 2025;42(8):1107-1120.  [Content Brief]