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Cat. No.: HY-168104

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VEGFR-2-IN-55

VEGFR-2-IN-55 (Compound 30) is a potent VEGFR-2 kinase inhibitor with an IC₅₀ value of 1.24 nM . VEGFR-2-IN-55 has antitumor activity.

For research use only. We do not sell to patients.

Formula: C₂₈H₂₁FN₄OS
Molecular Weight:480.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VEGFR-2-IN-55 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

VEGFR-2-IN-55 (Compound 30) is a potent VEGFR-2 kinase inhibitor with an IC₅₀ value of 1.24 nM . VEGFR-2-IN-55 has antitumor activity^[1].

IC₅₀ & Target

VEGFR-2

1.24 nM (IC₅₀)

All VEGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	GI₅₀	>10000 nM Compound: 30	Growth inhibition of mouse BaF3 incubated for 72 hrs by CCK-8 assay Growth inhibition of mouse BaF3 incubated for 72 hrs by CCK-8 assay	[PMID: 39353237]
BaF3	GI₅₀	1.42 nM Compound: 30	Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay	[PMID: 39353237]

Chemical Information

Molecular Weight 480.56
Formula C₂₈H₂₁FN₄OS
SMILES

O=C(NC1=CC=CC(SC2=CC3=C(C=C2)C(/C=C/C4=NC=CC=C4)=NN3)=C1)CC5=CC=CC=C5F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zha H, et al. Design, synthesis and biological evaluation of indazole derivatives as VEGFR-2 kinase inhibitors with anti-angiogenic properties. Eur J Med Chem. 2024 Sep 19;279:116889. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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VEGFR-2-IN-55

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VEGFR-2-IN-55 Related Classifications

HY-168104 Related Classifications