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Cat. No.: HY-182306

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VEGFR-2 ligand-2

VEGFR-2 ligand-1, Sorafenib (HY-10201) derivative, is a vascular endothelial growth factor receptor 2 (VEGFR2) ligand. VEGFR-2 ligand-1 binds to the ATP-binding pocket of VEGFR2, forms hydrophobic contacts and hydrogen bonds with key binding-site residues. VEGFR-2 ligand-1 can be used for the research angiogenesis-related pathologies.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₆ClF₃N₄O₄
Molecular Weight:492.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VEGFR-2 ligand-2 Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

VEGFR2

All VEGFR Isoforms :

In Vitro

VEGFR-2 ligand-1 (Compound Derivative 7) shows binding affinity for the human VEGFR2 kinase domain (PDB ID 3WZE) with a binding energy of -11.7 kcal/mol, through a network of hydrophobic contacts and hydrogen bonds with key active-site residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 492.84
Formula C₂₂H₁₆ClF₃N₄O₄
SMILES

CNC(C1=CC(OC2=CC=C(C=C2C=O)NC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O)=CC=N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Inan D, et al. AI fragmentation-based optimization of Sorafenib derivatives targeting VEGFR2 for angiogenesis-related pathologies: a structure-based in-silico study. Sci Rep. Published online March 3, 2026. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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VEGFR-2 ligand-2

All VEGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

VEGFR-2 ligand-2 Related Classifications

HY-182306 Related Classifications