VEGFR-2 ligand-2 

VEGFR-2 ligand-1, Sorafenib (HY-10201) derivative, is a vascular endothelial growth factor receptor 2 (VEGFR2) ligand. VEGFR-2 ligand-1 binds to the ATP-binding pocket of VEGFR2, forms hydrophobic contacts and hydrogen bonds with key binding-site residues. VEGFR-2 ligand-1 can be used for the research angiogenesis-related pathologies^[1].

VEGFR-2 ligand-1 (Compound Derivative 7) shows binding affinity for the human VEGFR2 kinase domain (PDB ID 3WZE) with a binding energy of -11.7 kcal/mol, through a network of hydrophobic contacts and hydrogen bonds with key active-site residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

492.84

C₂₂H₁₆ClF₃N₄O₄

CNC(C1=CC(OC2=CC=C(C=C2C=O)NC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O)=CC=N1)=O

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• [1]. Inan D, et al. AI fragmentation-based optimization of Sorafenib derivatives targeting VEGFR2 for angiogenesis-related pathologies: a structure-based in-silico study. Sci Rep. Published online March 3, 2026.  [Content Brief]