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Cat. No.: HY-P11916

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VH9

VH9 is a Free radical scavenger. VH9 binds to the active pocket of Keap1, blocks the interaction between Keap1 and Nrf2, and activates the Keap1-Nrf2 antioxidant pathway. VH9 inhibits ROS production. VH9 scavenges ABTS and DPPH free radicals through hydrogen bonding and hydrophobic interactions. VH9 protects cells from oxidative stress damage.

For research use only. We do not sell to patients.

Formula: C₄₈H₆₃N₁₁O₁₇
Molecular Weight:1066.08

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

VH9 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

VH9 exhibits potent ABTS radical scavenging activity in a cell-free assay, with an IC₅₀ of 19.698 μM^[1].
VH9 exhibits DPPH radical scavenging activity in a cell-free assay, with an IC₅₀ of 1500.825 μM^[1].
VH9 (0.1-3 mg/mL; 1-2 h) exhibits good stability across varying temperatures, pH levels, NaCl concentrations, and simulated gastrointestinal digestion, retaining significant radical scavenging activity under all tested conditions^[1].
VH9 (62.5-1500 μg/mL; 24 h) protects human HepG2 cells from H₂O₂-induced oxidative stress, increasing cell viability to up to 84.52% at a concentration of 1500 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human HepG2 cells
Concentration:

62.5-1500 μg/mL (VH9 pre-incubation); 800 μM (H₂O₂ incubation)
Incubation Time:

24 h (VH9 pre-incubation); 2 h (H₂O₂ incubation)
Result:

Significantly improved the viability of H₂O₂-damaged HepG2 cells, with cell viability reaching 65.67%, 80.39%, and 84.52% at concentrations of 500, 1000, and 1500 μg/mL, respectively.
Showed greater protective potency than FK10 at all tested concentrations.

Chemical Information

Molecular Weight 1066.08
Formula C₄₈H₆₃N₁₁O₁₇
Sequence

Val-Gly-Ser-Tyr-Glu-Asp-Pro-Tyr-His
Sequence Shortening

VGSYEDPYH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang D, et al. Identification and characterization of novel antioxidant peptides from Yunnan dry-cured beef: A combined in silico and in vitro study. Food chemistry. 2025 Jun 15;477:143485. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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