2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. VU6009453

VU6009453 (compound 15q) is a brain-penetrant M4 mAChR positive allosteric modulator (PAM) with an EC50 of 383 nM. VU6009453 can be used for research on neurological diseases.

For research use only. We do not sell to patients.

VU6009453

VU6009453 Chemical Structure

CAS No. : 2148929-11-5

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VU6009453 Related Antibodies

Top Publications Citing Use of Products

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

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Description

VU6009453 (compound 15q) is a brain-penetrant M4 mAChR positive allosteric modulator (PAM) with an EC50 of 383 nM. VU6009453 can be used for research on neurological diseases[1].

IC50 & Target[1]

mAChR4

383 nM (EC50)

Molecular Weight

396.88

Formula

C21H21ClN4O2
CAS No.
SMILES

O=C(NC1CN(C2=CC(=NC=C2Cl)OC)C1)C=3C=CC=4N=C(C=C(C4C3)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU6009453 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60094532148929-11-5VU 6009453VU-6009453mAChRMuscarinic acetylcholine receptorM4 mAChR positive allosteric modulatorbrain-penetrantInhibitorinhibitorinhibit

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