2. PROTAC Apoptosis Epigenetics
  3. PROTACs Apoptosis METTL3
  4. WD6305 TFA

WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity.(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

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WD6305 TFA

WD6305 TFA 構造式

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1220 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1220 在庫あり
Solid
1 mg $218 在庫あり
5 mg $545 在庫あり
10 mg $905 在庫あり
25 mg $1942 在庫あり
50 mg $3225 在庫あり
100 mg $5160 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 2 publication(s) in Google Scholar

Other Forms of WD6305 TFA:

WD6305 TFA 関連抗体

Top Publications Citing Use of Products

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

WD6305 TFA is a potent and selective METTL3-METTL14 PROTAC degrader. WD6305 TFA has DC50 values of 140 nM and 194 nM for METTL3 and METTL14, respectively. WD6305 TFA inhibits m6A modification and proliferation of AML cells, and induces apoptosis. WD6305 TFA has antitumor activity[1].(Pink: UZH2 (HY-115717); Black: Linker; Blue: VHL ligand (HY-150803))

IC50 & Target

DC50: 140 nM (METTL3); D max: 91.9% (METTL3) [1]
DC50: 194 nM (METTL14)[1]
体外実験

Non-salt dose:
WD6305 (20-5000 nM; 24 h) reduces METTL3 protein levels in Mono-Mac-6 cells with a DC50 of 140 nM and a D max of 91.9%[1].
WD6305 (20-5000 nM; 24 h) reduces METTL14 protein levels in Mono-Mac-6 cells with a DC50 of 194 nM[1].
WD6305 (0.5-10 μM; 48 h) decreases the ratio of m6A to polyA mRNA, inhibits cell proliferation and induces cell apoptosis in Mono-Mac-6 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

WD6305 TFA 関連抗体

Western Blot Analysis[1]

Cell Line: Mono-Mac-6 cells
Concentration: 20, 50, 100, 250, 500, 1000, 2000 and 5000 nM
Incubation Time: 24 h
Result: Reduced METTL3 and METTL14 protein levels in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: Mono-Mac-6 cells
Concentration: 1 and 2.5 μM
Incubation Time: 48 h
Result: Increased the levels of cleaved caspase-3 and cleaved PARP.
分子量

1226.40

分子式

C63H76F5N11O7S
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)CCC#CC(C=C4)=CC=C4CNC5=CC(N(CC6)CCC76NC(CN(C8=CC(F)=C(CN9CCC(C)(C)CC9)C=C8F)C7)=O)=NC=N5.O=C(O)C(F)(F)F
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外: 

DMSO : 95 mg/mL (77.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8154 mL 4.0770 mL 8.1539 mL
5 mM 0.1631 mL 0.8154 mL 1.6308 mL
10 mM 0.0815 mL 0.4077 mL 0.8154 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
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Calculation results:
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純度とドキュメンテーション

純度: 99.81%

COA (251 KB) HNMR (341 KB) CNMR (323 KB) RP-HPLC (263 KB) LCMS (108 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8154 mL 4.0770 mL 8.1539 mL 20.3849 mL
5 mM 0.1631 mL 0.8154 mL 1.6308 mL 4.0770 mL
10 mM 0.0815 mL 0.4077 mL 0.8154 mL 2.0385 mL
15 mM 0.0544 mL 0.2718 mL 0.5436 mL 1.3590 mL
20 mM 0.0408 mL 0.2038 mL 0.4077 mL 1.0192 mL
25 mM 0.0326 mL 0.1631 mL 0.3262 mL 0.8154 mL
30 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6795 mL
40 mM 0.0204 mL 0.1019 mL 0.2038 mL 0.5096 mL
50 mM 0.0163 mL 0.0815 mL 0.1631 mL 0.4077 mL
60 mM 0.0136 mL 0.0679 mL 0.1359 mL 0.3397 mL
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WD6305 TFA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WD6305WD 6305WD-6305PROTACsApoptosisMETTL3Methyltransferase-like 3AMLMono-Mac-6 cellsInhibitorinhibitorinhibit

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製品名:
WD6305 TFA
製品番号:
HY-160415A
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