XIAP antagonist 1
XIAP antagonist 1 degrades rather than inhibits XIAP, catalyzing rapid degradation of XIAP through the ubiquitin-proteasome pathway[2].
For research use only. We do not sell to patients.
- CAS No.: 375835-04-4
- Formula: C23H25ClN4O3
- Molecular Weight:440.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 375835-04-4
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Molecular Weight 440.92
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Formula C23H25ClN4O3
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SMILES
O=C(NC1=C(NC2=C1C=C(Cl)C=C2)C(OC)=O)CN(CC3)CCN3CC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dana Mamriev, et al. A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2. Cell Death Dis. 2020 Jun 25;11(6):483. [Content Brief]
[2]. Zhang'E Choo, et al. Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma. Cancer Res Commun. 2023 Nov 22;3(11):2386-2399. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
XIAP antagonist 1 Related Classifications
HY-157230 Related Classifications
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