ω-Agatoxin IVA

ω-Agatoxin IVA potently inhibits somatic P-type calcium channels in rat cerebellar Purkinje neurons with an IC₅₀ of 2 nM^[1].
ω-Agatoxin IVA inhibits Q-type calcium channels in rat cerebellar granule neurons with an IC₅₀ of 90 nM, which is 45-fold less potent than its activity against P-type channels^[1].
ω-Agatoxin IVA inhibits high potassium-induced glutamate exocytosis and calcium influx in rat cortical synaptosomes with IC₅₀ values ranging from 30 nM to 225 nM^[1].
ω-Agatoxin IVA (200 nM) inhibits cloned rat brain rbA-I and rbA-II calcium channel isoforms by only 20%^[1].
ω-Agatoxin IVA (100 nM) does not inhibit voltage-dependent calcium currents in cultured rat sympathetic neurons^[2].
ω-Agatoxin IVA (100 nM; 30 min) does not alter frequency-dependent neurogenic excitatory responses in isolated rabbit pulmonary artery ring preparations^[2].
ω-Agatoxin IVA (100 nM; 30 min) does not significantly inhibit neurogenic cholinergic excitatory responses in isolated guinea-pig myenteric plexus preparations^[2].
ω-Agatoxin IVA (100 nM; 30 min) does not significantly inhibit neurogenic noradrenergic excitatory responses in isolated rat vas deferens preparations^[2].
ω-Agatoxin IVA (100 nM; 30 min) does not significantly inhibit neurogenic excitatory responses in isolated rat bladder strip preparations^[2].
ω-Agatoxin IVA (100 nM; 30 min) does not significantly inhibit neurogenic noradrenergic excitatory responses in isolated rat anococcygeus muscle preparations^[2].
ω-Agatoxin IVA (100 nM; 30 min) does not significantly alter neurogenic NANC inhibitory responses in isolated Atropine (HY-B1205)/Guanethidine (HY-B1251)-treated rat anococcygeus muscle and jejunum preparations preparations^[2].
ω-Agatoxin IVA (0.1 μmol/L; 30 min) potently inhibits Capsaicin (HY-10448)-induced CGRP release from isolated rat pial arteries^[3].

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