α-CGRP (mouse, rat) (Synonyms: CGRP (83-119), mouse, rat)

Name: α-CGRP (mouse, rat)
Brand: MedChemExpress
SKU: HY-P0203
Rating: 5.0 (8 reviews)

Cat. No.: HY-P0203 Purity: 99.80%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

CAS No. : 83651-90-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	Get quote
50 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of α-CGRP (mouse, rat):

β-CGRP (mouse) In-stock
α-CGRP (mouse, rat) TFA In-stock

8 Publications Citing Use of MCE α-CGRP (mouse, rat)

RT-PCR

In Vivo Efficacy Study

Flow Cytometry

ELISA

Histological Imaging/Staining

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]; CGRP stimulation (100 nM, 96 hours) up-regulated the expression of Prdm12 and Ramp1.

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]; Wild-type CD8+ T cells treated with CGRP (100 nM, 96 hours) exhibited an elevated frequency of PD-1+TIM-3+ cells, whereas this effect was reversed by Prdm12 knockout (KO).

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 Aug 15;11(33):eadx9221. [Abstract]; Wild-type CD8+ T cells treated with CGRP (100 nM, 96 hours) exhibited a reduced frequency of CD107a+ cells, and Prdm12 KO abrogated this reduction.

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]; CGRP (50 μg/kg, intraperitoneal injection,on days 1, 2, and 3) reduced the frequency and severity of epileptic seizures mice induced by Kainic acid(1 μL, 250 ng/μL,single ).

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]; CGRP (50 μg/kg, intraperitoneal injection, on days 1, 2, and 3) reduced the expression of pro-inflammatory cytokines (including IL-1β, IL-6, and TNF-α) in the brain tissues of epileptic mice induced by kainic acid.

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]; CGRP (50 μg/kg, intraperitoneal injection, on days 1, 2, and 3) mitigated pathological damage in the CA1 and CA3 regions of the hippocampus in epileptic mice induced by kainic acid, as revealed by hematoxylin and eosin staining (left) and Nissl staining (right).

: α-CGRP (mouse, rat) purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2025 Dec 21:170:116080. [Abstract]; CGRP (50 μg/kg, intraperitoneal injection,on days 1, 2, and 3) reduced epilepsy-induced hippocampal apoptosis and neuronal loss in epilepsy mice induced by Kainic acid .

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

α-CGRP (mouse, rat) can regulate the innate lymphoid cell response in 2 groups^[1].
α-CGRP (mouse, rat) regulates insulin secretion and reduces the risk of type 2 diabetes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged^[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

3806.25

Formula

C₁₆₂H₂₆₂N₅₀O₅₂S₂

CAS No.

83651-90-5

Appearance

Solid

Color

White to off-white

Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)

Sequence Shortening

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : ≥ 100 mg/mL (26.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.2627 mL	1.3136 mL	2.6273 mL
5 mM	0.0525 mL	0.2627 mL	0.5255 mL
10 mM	0.0263 mL	0.1314 mL	0.2627 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (290 KB) SDS (254 KB)

COA (266 KB) RP-HPLC (253 KB) MS (213 KB)

Handling Instructions (2659 KB)

References

[1]. Whitby K, et al. Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo. J Virol. 2005 Jul;79(14):8698-706. [Content Brief]

[2]. Xu H, et al. Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses. Immunity. 2019 Oct 15;51(4):696-708.e9. [Content Brief]

[3]. Arulmani U, et al. Effects of the calcitonin gene-related peptide (CGRP) receptor antagonist BIBN4096BS on alpha-CGRP-induced regional haemodynamic changes in anaesthetised rats. Basic Clin Pharmacol Toxicol. 2004 Jun;94(6):291-7. [Content Brief]

[4]. Park SH, et al. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	0.2627 mL	1.3136 mL	2.6273 mL	6.5681 mL
	5 mM	0.0525 mL	0.2627 mL	0.5255 mL	1.3136 mL
	10 mM	0.0263 mL	0.1314 mL	0.2627 mL	0.6568 mL
	15 mM	0.0175 mL	0.0876 mL	0.1752 mL	0.4379 mL
	20 mM	0.0131 mL	0.0657 mL	0.1314 mL	0.3284 mL
	25 mM	0.0105 mL	0.0525 mL	0.1051 mL	0.2627 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

α-CGRP (mouse, rat) Related Classifications

Metabolic Disease Inflammation/Immunology Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-CGRP (mouse, rat)83651-90-5CGRP (83-119), mouse, ratCGRP ReceptorCalcitonin gene-related peptide receptorvasodilatorcardiovascularpro-inflammatorymigraineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

α-CGRP (mouse, rat) (Synonyms: CGRP (83-119), mouse, rat)

Customer Review

Other Forms of α-CGRP (mouse, rat):

α-CGRP (mouse, rat) Related Antibodies

8 Publications Citing Use of MCE α-CGRP (mouse, rat)

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

α-CGRP (mouse, rat) Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

α-CGRP (mouse, rat) Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report