1β-Hydroxybaccatin I
Based on 1 Customer Validation
1β-Hydroxybaccatin I (1-Hydroxybaccatin I) can be extracted from Taxus wallichiana.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 30244-37-2
- Formula: C32H44O14
- Molecular Weight:652.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| KB | IC50 |
>10 μg/mL
Compound: 31
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Cytotoxicity against human epidermoid carcinoma KB cells
Cytotoxicity against human epidermoid carcinoma KB cells
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10.1016/S0960-894X(97)00029-2 |
| L1210 | IC50 |
>10 μg/mL
Compound: 31
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Cytotoxicity against murine leukemia L1210 cells
Cytotoxicity against murine leukemia L1210 cells
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10.1016/S0960-894X(97)00029-2 |
Chemical Information
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CAS No. 30244-37-2
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Appearance Solid
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Molecular Weight 652.68
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Formula C32H44O14
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Color White to off-white
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SMILES
C[C@]1([C@@H](OC(C)=O)[C@H](OC(C)=O)C2=C(C)[C@@H](OC(C)=O)C[C@]3(O)C2(C)C)[C@@]([C@@H]3OC(C)=O)([H])[C@]4(OC4)[C@@H](OC(C)=O)C[C@@H]1OC(C)=O
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Synonyms
1-Hydroxybaccatin I
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (76.61 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.83 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5321 mL | 7.6607 mL | 15.3214 mL | 38.3036 mL |
| 5 mM | 0.3064 mL | 1.5321 mL | 3.0643 mL | 7.6607 mL | |
| 10 mM | 0.1532 mL | 0.7661 mL | 1.5321 mL | 3.8304 mL | |
| 15 mM | 0.1021 mL | 0.5107 mL | 1.0214 mL | 2.5536 mL | |
| 20 mM | 0.0766 mL | 0.3830 mL | 0.7661 mL | 1.9152 mL | |
| 25 mM | 0.0613 mL | 0.3064 mL | 0.6129 mL | 1.5321 mL | |
| 30 mM | 0.0511 mL | 0.2554 mL | 0.5107 mL | 1.2768 mL | |
| 40 mM | 0.0383 mL | 0.1915 mL | 0.3830 mL | 0.9576 mL | |
| 50 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7661 mL | |
| 60 mM | 0.0255 mL | 0.1277 mL | 0.2554 mL | 0.6384 mL |
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