2. Apoptosis
  3. Apoptosis
  4. 2,4,6-Triiodophenol

2,4,6-Triiodophenol is an orally active and potent leukotriene B4 (LTB4) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis.

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2,4,6-Triiodophenol Chemical Structure

2,4,6-Triiodophenol Chemical Structure

CAS No. : 609-23-4

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2,4,6-Triiodophenol Related Antibodies

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Description

2,4,6-Triiodophenol is an orally active and potent leukotriene B4 (LTB4) synthesis inhibitor. 2,4,6-Triiodophenol can induce mouse blastocysts apoptosis[1][2].

In Vitro

2,4,6-Triiodophenol (5-50 μM; 0-100 h) impairs the quality of pre-implantation mouse embryos in a dose-dependent manner, inducing decline of both total and trophectoderm cell numbers[2].
2,4,6-Triiodophenol (5 μM; 85 h) shows increasement of apoptotic cells in mouse pre-implantation embryos[2].
2,4,6-Triiodophenol (5-50 μM; 100 h) induces oxidative stress in mouse pre-implantation embryos[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,4,6-Triiodophenol Related Antibodies

Apoptosis Analysis[2]

Cell Line: Mouse blastocyst cells
Concentration: 5 μM
Incubation Time: 85 hours
Result: Showed signals of activated Caspase-3/7.

Immunofluorescence[2]

Cell Line: Mouse blastocyst cells
Concentration: 5-50 μM
Incubation Time: 100 hours
Result: Resulted in marked increase of oxygen species (ROS) treated with high dose of 2,4,6-Triiodophenol.
Molecular Weight

471.80

Formula

C6H3I3O
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

OC1=C(I)C=C(I)C=C1I
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (529.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1195 mL 10.5977 mL 21.1954 mL
5 mM 0.4239 mL 2.1195 mL 4.2391 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.29%

COA (247 KB) HNMR (123 KB) RP-HPLC (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1195 mL 10.5977 mL 21.1954 mL 52.9886 mL
5 mM 0.4239 mL 2.1195 mL 4.2391 mL 10.5977 mL
10 mM 0.2120 mL 1.0598 mL 2.1195 mL 5.2989 mL
15 mM 0.1413 mL 0.7065 mL 1.4130 mL 3.5326 mL
20 mM 0.1060 mL 0.5299 mL 1.0598 mL 2.6494 mL
25 mM 0.0848 mL 0.4239 mL 0.8478 mL 2.1195 mL
30 mM 0.0707 mL 0.3533 mL 0.7065 mL 1.7663 mL
40 mM 0.0530 mL 0.2649 mL 0.5299 mL 1.3247 mL
50 mM 0.0424 mL 0.2120 mL 0.4239 mL 1.0598 mL
60 mM 0.0353 mL 0.1766 mL 0.3533 mL 0.8831 mL
80 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.6624 mL
100 mM 0.0212 mL 0.1060 mL 0.2120 mL 0.5299 mL
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2,4,6-Triiodophenol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,4,6-Triiodophenol609-23-4Apoptosismouse blastocyst cellInhibitorinhibitorinhibit

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