2-Hydroxy-3-methoxychalcone
2-Hydroxy-3-methoxychalcone is a methoxy-derivative of 2'-Hydroxychalcone with an anticancer activity.
For research use only. We do not sell to patients.
- CAS No.: 7146-86-3
- Formula: C16H14O3
- Molecular Weight:254.28
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Neutrophil | IC50 |
3 μM
Compound: 10
|
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 5.5 mM glucose by luminol-amplified chemiluminescence method
|
[PMID: 33006891] |
| Neutrophil | IC50 |
5.7 μM
Compound: 10
|
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
Inhibition of PMA-induce ROS/RNS generation in human neutrophils measured up to 30 mins in presence of 30 mM glucose by luminol-amplified chemiluminescence method
|
[PMID: 33006891] |
| THP-1 | CC50 |
>25 μM
Compound: 1
|
Cytotoxicity against human THP1 cells by MTT assay
Cytotoxicity against human THP1 cells by MTT assay
|
[PMID: 28064141] |
2-Hydroxy-3-methoxychalcone (TJ3) (10 µM and 25 µM) significantly reduces the concentration of MIF secreted by SW480 cells which correlates with downregulations of ICAM-1. 2-Hydroxy-3-methoxychalcone (25 µM) increases the concentration of IL-8 in SW480 and SW620 cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 7146-86-3
-
Molecular Weight 254.28
-
Formula C16H14O3
-
SMILES
O=C(C1=CC=CC=C1O)C=CC2=CC=CC(OC)=C2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2-Hydroxy-3-methoxychalcone Related Classifications
HY-W411442 Related Classifications
Powered by Bioz