2-Iodoaniline
Based on 1 Customer Validation
2-Iodoaniline (2-Iodophenylamine) is an aniline derivative, and has potential hepatotoxic and nephrotoxic activity.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 615-43-0
- Formula: C6H6IN
- Molecular Weight:219.03
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Fischer 344 rats (185-260 g)[1]
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Dosage:1.0 mM/kg, 1.25 mM/kg for 2.5 mL
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Administration:Intraperitoneal injection; single dose; monitored renal and hepatic function 24 h after treatment
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Result:Induced oliguria, diminished kidney weight, tubular casts and decreased renal cortical slice accumulation of organic anions.
Elevated plasma ALT/GPT activity and altered morphology in the centrilobular region.
Chemical Information
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CAS No. 615-43-0
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Appearance Solid
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Molecular Weight 219.03
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Formula C6H6IN
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Color White to light brown
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SMILES
IC1=CC=CC=C1N
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Synonyms
2-Iodophenylamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (456.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (22.83 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5657 mL | 22.8284 mL | 45.6569 mL | 114.1422 mL |
| 5 mM | 0.9131 mL | 4.5657 mL | 9.1314 mL | 22.8284 mL | |
| 10 mM | 0.4566 mL | 2.2828 mL | 4.5657 mL | 11.4142 mL | |
| 15 mM | 0.3044 mL | 1.5219 mL | 3.0438 mL | 7.6095 mL | |
| 20 mM | 0.2283 mL | 1.1414 mL | 2.2828 mL | 5.7071 mL | |
| 25 mM | 0.1826 mL | 0.9131 mL | 1.8263 mL | 4.5657 mL | |
| 30 mM | 0.1522 mL | 0.7609 mL | 1.5219 mL | 3.8047 mL | |
| 40 mM | 0.1141 mL | 0.5707 mL | 1.1414 mL | 2.8536 mL | |
| 50 mM | 0.0913 mL | 0.4566 mL | 0.9131 mL | 2.2828 mL | |
| 60 mM | 0.0761 mL | 0.3805 mL | 0.7609 mL | 1.9024 mL | |
| 80 mM | 0.0571 mL | 0.2854 mL | 0.5707 mL | 1.4268 mL | |
| 100 mM | 0.0457 mL | 0.2283 mL | 0.4566 mL | 1.1414 mL |
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