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Cat. No.: HY-174120

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2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium

Name: 2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium
Brand: MedChemExpress
SKU: HY-174120
Availability: PreOrder

(Synonyms: 2-Thio-dCTP tetralithium)

2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium (2-Thio-dCTP tetralithium) is a dCTP (HY-101400A) analog that serves as a substrate for Sulfolobus solfataricus DNA polymerase Dpo4. 2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium incorporates opposite G and O⁶-MeG templates, exhibiting improved selectivity for O⁶-MeG relative to dCTP without significant loss of incorporation efficiency.

For research use only. We do not sell to patients.

CAS No.: 3056945-18-4
Formula: C₉H₁₂Li₄N₃O₁₂P₃S
Molecular Weight:506.95

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium Chemical Structure

CAS No.: 3056945-18-4

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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

2-Thio-2'-deoxycytidine-5'-triphosphate (400-800 µM; 45 min) tetralithium is efficiently incorporated opposite both G and O₆-MeG by Dpo4, showing similar efficiency to dCTP opposite the lesion^[1].
2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium displays an improved selectivity for incorporation opposite O⁶-MeG by Dpo4 without a significant loss of efficiency compared to dCTP^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 3056945-18-4
Molecular Weight 506.95
Formula C₉H₁₂Li₄N₃O₁₂P₃S
SMILES

NC(C=CN1[C@H]2C[C@H](O)[C@@H](COP(OP(OP(O[Li])(O[Li])=O)(O[Li])=O)(O[Li])=O)O2)=NC1=S
Synonyms

2-Thio-dCTP tetralithium
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stornetta A, et al. Incorporation of nucleoside probes opposite O⁶-methylguanine by Sulfolobus solfataricus DNA polymerase Dpo4: importance of hydrogen bonding. Chembiochem : a European journal of chemical biology. 2013 Sep 02;14(13):1634-9.

[2]. Gül OT, et al. Single Molecule Bioelectronics and Their Application to Amplification-Free Measurement of DNA Lengths. Biosensors. 2016 Jun 24;6(3):29. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium

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2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium

All DNA/RNA Synthesis Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium Related Classifications

HY-174120 Related Classifications

Bioz

Keywords

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