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Cat. No.: HY-N3426A

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(2R)-Kazinol B

(2R)-Kazinol B is a prenylated flavane enantiomer found in the stem and root barks of Daphne giraldii, and it is also an isomer of Kazinol B (HY-N3426). (2R)-Kazinol B exerts selective cytotoxicity against liver cancer cells, induces apoptosis via both intrinsic and extrinsic pathways, and triggers protective autophagy through AMPK activation. (2R)-Kazinol B can be used in the research of liver cancer.

For research use only. We do not sell to patients.

CAS No.: 2097138-89-9
Formula: C₂₅H₂₈O₄
Molecular Weight:392.49

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Please store the product under the recommended conditions in the Certificate of Analysis.

(2R)-Kazinol B Chemical Structure

CAS No.: 2097138-89-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
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Biological Activity

Description

IC₅₀ & Target

^[1]

AMPK

All AMPK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Hep3B	IC50	30.3 μM	Antiproliferative activity against human Hep3B hepatic carcinoma cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay. Antiproliferative activity against human Hep3B hepatic carcinoma cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay.	28371676
A549	IC₅₀	100 μM Compound: (+)-4	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 28371676]
Hep 3B2	IC₅₀	30.3 μM Compound: (+)-4	Cytotoxicity against human Hep3B cells by MTT assay Cytotoxicity against human Hep3B cells by MTT assay	[PMID: 28371676]
HepG2	IC₅₀	64.2 μM Compound: (+)-4	Cytotoxicity against human HepG2 cells by MTT assay Cytotoxicity against human HepG2 cells by MTT assay	[PMID: 28371676]
MCF7	IC₅₀	100 μM Compound: (+)-4	Cytotoxicity against human MCF7 cells by MTT assay Cytotoxicity against human MCF7 cells by MTT assay	[PMID: 28371676]

In Vitro

(2R)-Kazinol B (compound (±)-4) (6.25-100 μM; 48 h) potently inhibits the proliferation of human hepatocellular carcinoma Hep3B cells, with an IC₅₀ value of 30.3 μM^[1].
(2R)-Kazinol B (15-60 μM) activates AMPK in human hepatocellular carcinoma Hep3B cells, and this activation is positively correlated with the protective autophagy induced by (2R)-Kazinol B^[1].
(2R)-Kazinol B (15-60 μM; 48 h) induces apoptosis and autophagy in human hepatocellular carcinoma Hep3B cells via intrinsic and extrinsic pathways^[1].
(2R)-Kazinol B (30 μM)‑induced autophagy exerts a protective effect against apoptotic death in human hepatocellular carcinoma Hep3B cells, and inhibition of autophagy enhances (2R)-kazinol B‑mediated apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2097138-89-9
Molecular Weight 392.49
Formula C₂₅H₂₈O₄
SMILES

C/C(C)=C\CC1=C([C@@H]2OC3=CC(O)=CC=C3CC2)C=C4C(OC(C)(C=C4)C)=C1O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sun Q, et al. Autophagy antagonizes apoptosis induced by flavan enantiomers from Daphne giraldii in hepatic carcinoma cells in vitro. European journal of medicinal chemistry. 2017 Jun 16;133:1-10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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