4-Aminophenylphosphorylcholine
Based on 1 Customer Validation
4-Aminophenylphosphorylcholine ((p-Aminophenyl) phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC) is a phosphatidylcholine derivative that serves as a coupling ligand and antigen probe. When conjugated with gold nanoclusters, the phosphocholine head epitope of 4-Aminophenylphosphorylcholine is specifically recognized by anti-Pc IgM and CRP. It can be covalently coupled to human serum albumin (HSA) or glutathione-protected gold nanoclusters (Au-GSH) via covalent chemistry, respectively. The 4-Aminophenylphosphorylcholine-HSA complex acts as an ELISA coating antigen for detecting endogenous anti-Pc IgM antibodies in plasma; 4-Aminophenylphosphorylcholine-modified Au-GSH can be used to construct an ultra-stealthy NIR-II fluorescent gold nanocluster probe for imaging-related studies in mouse breast cancer and colon cancer models.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.73%
- CAS 番号: 102185-28-4
- 分子式: C11H19N2O4P
- 分子量:274.25
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
4-Aminophenylphosphorylcholine (PC) can covalently conjugate with Au25 (GSH)18 gold nanoclusters to form the Au-PC conjugate with excellent stability. When incubated with FBS, this conjugate exhibits an extremely low serum protein binding rate (binding efficiency of 1.74%) and shows no cytotoxicity against 4T1 mouse breast cancer cells and CT26 colon cancer cells[1].
4-Aminophenylphosphorylcholine (p-Aminophenylphosphorylcholine) successfully binds to human serum albumin under specified reaction conditions to form the Pc-HSA capture antigen, and this conjugate specifically detects anti-phosphocholine IgM in human plasma/serum[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 102185-28-4
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性状 Solid
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分子量 274.25
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分子式 C11H19N2O4P
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Color White to yellow
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SMILES
O=P(OCC[N+](C)(C)C)(OC1=CC=C(N)C=C1)[O-]
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別名
(p-Aminophenyl)phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
体外:
DMSO : 50 mg/mL (182.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (182.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.6463 mL | 18.2315 mL | 36.4631 mL | 91.1577 mL |
| 5 mM | 0.7293 mL | 3.6463 mL | 7.2926 mL | 18.2315 mL | |
| 10 mM | 0.3646 mL | 1.8232 mL | 3.6463 mL | 9.1158 mL | |
| 15 mM | 0.2431 mL | 1.2154 mL | 2.4309 mL | 6.0772 mL | |
| 20 mM | 0.1823 mL | 0.9116 mL | 1.8232 mL | 4.5579 mL | |
| 25 mM | 0.1459 mL | 0.7293 mL | 1.4585 mL | 3.6463 mL | |
| 30 mM | 0.1215 mL | 0.6077 mL | 1.2154 mL | 3.0386 mL | |
| 40 mM | 0.0912 mL | 0.4558 mL | 0.9116 mL | 2.2789 mL | |
| 50 mM | 0.0729 mL | 0.3646 mL | 0.7293 mL | 1.8232 mL | |
| 60 mM | 0.0608 mL | 0.3039 mL | 0.6077 mL | 1.5193 mL | |
| 80 mM | 0.0456 mL | 0.2279 mL | 0.4558 mL | 1.1395 mL | |
| 100 mM | 0.0365 mL | 0.1823 mL | 0.3646 mL | 0.9116 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
4-Aminophenylphosphorylcholine 関連分類
HY-113553 関連分類
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Keywords
- 4-Aminophenylphosphorylcholine
- 102185-28-4
- (p-Aminophenyl)phosphocholine
- p-Aminophenylphosphorylcholine
- 4-APPC
- Drug Derivative
- Drug Intermediate
- anti-phosphorylcholine IgM antibodies
- renal clearance
- tissues
- gold molecular clusters
- cells
- human serum albumin
- phosphorylcholine
- proteins
- murine cancer models
- NIR-II fluorescence imaging
- Inhibitor
- inhibitor
- inhibit