4-Aminophenylphosphorylcholine
Based on 1 Customer Validation
4-Aminophenylphosphorylcholine ((p-Aminophenyl) phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC) is a phosphatidylcholine derivative that serves as a coupling ligand and antigen probe. When conjugated with gold nanoclusters, the phosphocholine head epitope of 4-Aminophenylphosphorylcholine is specifically recognized by anti-Pc IgM and CRP. It can be covalently coupled to human serum albumin (HSA) or glutathione-protected gold nanoclusters (Au-GSH) via covalent chemistry, respectively. The 4-Aminophenylphosphorylcholine-HSA complex acts as an ELISA coating antigen for detecting endogenous anti-Pc IgM antibodies in plasma; 4-Aminophenylphosphorylcholine-modified Au-GSH can be used to construct an ultra-stealthy NIR-II fluorescent gold nanocluster probe for imaging-related studies in mouse breast cancer and colon cancer models.
For research use only. We do not sell to patients.
- Purity: 99.73%
- CAS No.: 102185-28-4
- Formula: C11H19N2O4P
- Molecular Weight:274.25
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Storage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
4-Aminophenylphosphorylcholine (PC) can covalently conjugate with Au25 (GSH)18 gold nanoclusters to form the Au-PC conjugate with excellent stability. When incubated with FBS, this conjugate exhibits an extremely low serum protein binding rate (binding efficiency of 1.74%) and shows no cytotoxicity against 4T1 mouse breast cancer cells and CT26 colon cancer cells[1].
4-Aminophenylphosphorylcholine (p-Aminophenylphosphorylcholine) successfully binds to human serum albumin under specified reaction conditions to form the Pc-HSA capture antigen, and this conjugate specifically detects anti-phosphocholine IgM in human plasma/serum[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 102185-28-4
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Appearance Solid
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Molecular Weight 274.25
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Formula C11H19N2O4P
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Color White to yellow
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SMILES
O=P(OCC[N+](C)(C)C)(OC1=CC=C(N)C=C1)[O-]
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Synonyms
(p-Aminophenyl)phosphocholine; p-Aminophenylphosphorylcholine; 4-APPC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (182.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (182.32 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.6463 mL | 18.2315 mL | 36.4631 mL | 91.1577 mL |
| 5 mM | 0.7293 mL | 3.6463 mL | 7.2926 mL | 18.2315 mL | |
| 10 mM | 0.3646 mL | 1.8232 mL | 3.6463 mL | 9.1158 mL | |
| 15 mM | 0.2431 mL | 1.2154 mL | 2.4309 mL | 6.0772 mL | |
| 20 mM | 0.1823 mL | 0.9116 mL | 1.8232 mL | 4.5579 mL | |
| 25 mM | 0.1459 mL | 0.7293 mL | 1.4585 mL | 3.6463 mL | |
| 30 mM | 0.1215 mL | 0.6077 mL | 1.2154 mL | 3.0386 mL | |
| 40 mM | 0.0912 mL | 0.4558 mL | 0.9116 mL | 2.2789 mL | |
| 50 mM | 0.0729 mL | 0.3646 mL | 0.7293 mL | 1.8232 mL | |
| 60 mM | 0.0608 mL | 0.3039 mL | 0.6077 mL | 1.5193 mL | |
| 80 mM | 0.0456 mL | 0.2279 mL | 0.4558 mL | 1.1395 mL | |
| 100 mM | 0.0365 mL | 0.1823 mL | 0.3646 mL | 0.9116 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
4-Aminophenylphosphorylcholine Related Classifications
HY-113553 Related Classifications
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Keywords
- 4-Aminophenylphosphorylcholine
- 102185-28-4
- (p-Aminophenyl)phosphocholine
- p-Aminophenylphosphorylcholine
- 4-APPC
- Drug Derivative
- Drug Intermediate
- anti-phosphorylcholine IgM antibodies
- renal clearance
- tissues
- gold molecular clusters
- cells
- human serum albumin
- phosphorylcholine
- proteins
- murine cancer models
- NIR-II fluorescence imaging
- Inhibitor
- inhibitor
- inhibit