5-Cyanoindole
Based on 1 Customer Validation
5-Cyanoindole is a human myeloperoxidase (MPO) inhibitor. 5-Cyanoindole specifically inhibits breast cancer cell proliferation. 5-Cyanoindole can be used in research on inflammation and breast cancer.
For research use only. We do not sell to patients.
- Purity : 99.95%
- CAS No.: 15861-24-2
- Formula: C9H6N2
- Molecular Weight:142.16
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-Y0061
Oxindole -
HY-137884
3-Indolyl acetateBiochemical Assay Reagent -
HY-W015273
3-Indoleacrylic acidAntialgal Agent -
HY-Y0136
3-IndoleacetonitrileAntiviral Agent -
HY-W007349
6-Methyl-1H-indoleBiochemical Reagent -
HY-W001972
5-MethylindoleBiochemical Reagent -
HY-Y0136R
3-Indoleacetonitrile (Standard)Antiviral Agent -
HY-W001974
7-NitroindoleGrowth Inhibitor, Klenow fragment Ligand, DNA backbone Cleavage Inducer, DNA duplex Destabilizer -
HY-W007642
6-BenzyloxyindoleBiochemical Reagent -
HY-30236
5-BromoindoleAntibacterial Agent -
HY-Y0061R
Oxindole (Standard)
Biological Activity
Description
IC50 & Target
[1]|
MPO |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
40.5 μM
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Antiproliferative activity against human breast cancer MDA-MB-231 cells in vitro.
Antiproliferative activity against human breast cancer MDA-MB-231 cells in vitro.
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42681845 |
| MCF7 | IC50 |
41.0 μM
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Antiproliferative activity against human breast cancer MCF7 cells in vitro.
Antiproliferative activity against human breast cancer MCF7 cells in vitro.
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42681845 |
| T47D | IC50 |
3.5 μM
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Antiproliferative activity against human breast cancer T47D cells in vitro.
Antiproliferative activity against human breast cancer T47D cells in vitro.
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42681845 |
In Vitro
Compound 14 (3.5 μM), the 5-cyanoindole-derived indolylkojylmethane, specifically inhibits T47D breast cancer cell proliferation with an IC50 of 3.5 μM[6].
5-Cyanoindole inhibits human myeloperoxidase-mediated chlorination of monochlorodimedon with IC50 = 13.2 μM at pH 7.0 and IC50 = 135 μM at pH 5.0[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- BrdU Incorporation Assay
- Somatic Cell Culture
- CFSE Dye Dilution Proliferation Assay
- Dye-dilution cell tracking and proliferation staining
- CCK-8/WST-8 Cell Proliferation Assay
- Protocol for Cell Cycle
- Cell Counting-Based Growth Curve Assay
- Research Protocol for Inflammation-related Diseases
- Colony Formation (Clonogenic) Assay
- Breast Cancer Modeling
- Cell Viability Determination by MTT Colorimetric Assay
- EdU Incorporation Assay (Click Chemistry-Based DNA Synthesis Measurement)
- Ki-67 Immunostaining Proliferation Assay
- PCNA Immunodetection Proliferation Assay
- Protocol for Cell Counting and Cell Density Analysis
- MTT Cell Proliferation Assay
Chemical Information
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CAS No. 15861-24-2
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Appearance Solid
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Molecular Weight 142.16
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Formula C9H6N2
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Color Light yellow to light brown
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SMILES
N#CC1=CC=C2NC=CC2=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (703.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[2]. Heinrich T, et al. Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. Journal of medicinal chemistry. 2004 Sep 09;47(19):4684-92. [Content Brief]
[5]. Hatzenbuhler NT, et al. Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. Journal of medicinal chemistry. 2008 Nov 13;51(21):6980-7004. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.0343 mL | 35.1716 mL | 70.3433 mL | 175.8582 mL |
| 5 mM | 1.4069 mL | 7.0343 mL | 14.0687 mL | 35.1716 mL | |
| 10 mM | 0.7034 mL | 3.5172 mL | 7.0343 mL | 17.5858 mL | |
| 15 mM | 0.4690 mL | 2.3448 mL | 4.6896 mL | 11.7239 mL | |
| 20 mM | 0.3517 mL | 1.7586 mL | 3.5172 mL | 8.7929 mL | |
| 25 mM | 0.2814 mL | 1.4069 mL | 2.8137 mL | 7.0343 mL | |
| 30 mM | 0.2345 mL | 1.1724 mL | 2.3448 mL | 5.8619 mL | |
| 40 mM | 0.1759 mL | 0.8793 mL | 1.7586 mL | 4.3965 mL | |
| 50 mM | 0.1407 mL | 0.7034 mL | 1.4069 mL | 3.5172 mL | |
| 60 mM | 0.1172 mL | 0.5862 mL | 1.1724 mL | 2.9310 mL | |
| 80 mM | 0.0879 mL | 0.4396 mL | 0.8793 mL | 2.1982 mL | |
| 100 mM | 0.0703 mL | 0.3517 mL | 0.7034 mL | 1.7586 mL |
5-Cyanoindole Related Classifications
HY-77057 Related Classifications
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