2. GPCR/G Protein
  3. G protein-coupled Bile Acid Receptor 1
  4. 6ECA

6ECA is a selective TGR5 receptor activator with an EC50 of 3.44 μM. 6ECA shows no significant activity at FXR. 6ECA can be used for the study of diabesity.

For research use only. We do not sell to patients.

6ECA

6ECA Chemical Structure

CAS No. : 647011-80-1

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6ECA Related Antibodies

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Description

6ECA is a selective TGR5 receptor activator with an EC50 of 3.44 μM. 6ECA shows no significant activity at FXR. 6ECA can be used for the study of diabesity[1].

IC50 & Target[1]

TGR5 receptor

3.44 μM (EC50)

In Vitro

6ECA (compound 14) acts as a TGR5 agonist in CHO cells transiently transfected with human TGR5 with an EC50 of 3.44 μM and has no FXR agonist activity in COS1 cells (EC50 >100 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6ECA Related Antibodies
Molecular Weight

436.62

Formula

C26H44O5
CAS No.
SMILES

C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6ECA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6ECA647011-80-1G protein-coupled Bile Acid Receptor 1G-protein coupled receptor 19GPCR19TGR5GPBAR1CHO cellsTGR5 receptorhuman TGR5farnesoid-X receptorCOS1 cellsInhibitorinhibitorinhibit

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HY-41333
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