A 419259 trihydrochloride
Based on 12 publication(s) in Google Scholar
A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively.
For research use only. We do not sell to patients.
- Purity : 98.28%
- CAS No.: 1435934-25-0
- Formula: C29H37Cl3N6O
- Molecular Weight:592.00
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) A 419259 trihydrochloride
More- Blood. 2016 Jun 23;127(25):3237-52. [Abstract]
- Adv Sci (Weinh). 2025 Jun 30:e17764. [Abstract]
- Clin Transl Med. 2026 Jul;16(7):e70731.
- Aging Cell. 2026 Jan 20;25(2):e70352.
- J Med Chem. 2024 Nov 28;67(22):20571-20579. [Abstract]
- Commun Biol. 2026 Apr 9;9(1):780. [Abstract]
- Microb Pathog. 2025 Feb:199:107252. [Abstract]
- Biochem Biophys Res Commun. 2026 Aug 27:828:154112. [Abstract]
- Res Sq. 2026 May 8:rs.3.rs-9500406. [Abstract]
- Free University of Berlin. 2025 Aug 4.
- Patent. US20250228856A1.
- Patent. US20170333436A1.
Biological Activity
Description
IC50 & Target
IC50: 9 nM (Src), <3 nM (Lck), <3 nM (Lyn), 3 μM (Abl)[1]
In Vitro
"A419259 is a second-generation pyrrolopyrimidine that blocks proliferation and induces apoptosis in CML cell lines. It induces apoptosis in K-562 cells and also inhibits Meg-01 proliferation (IC50=0.1 μM)[1].
In the absence of IL-3, A-419259 strongly inhibits DAGM/Bcr-Abl cell proliferation (IC50=0.1-0.3 μM)[1].
A-419259 also inhibits overall SFK activity in CML cell lines and blocks Src kinase activation (IC50=0.1-0.3 μM)[1].
A 419259 trihydrochloride (1 μM; 16 h) inhibits endogenous SFK (c-Src and Lck) activity, thereby inhibiting Src-driven differentiation of mES cells toward primitive ectoderm-like cells[2].
A 419259 trihydrochloride (0.3, 1 μM; 5 days) has no effect on undifferentiated colony morphology of hES cells grown in mTeSR medium[2].
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1435934-25-0
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Appearance Solid
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Molecular Weight 592.00
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Formula C29H37Cl3N6O
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Color White to yellow
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SMILES
NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1.[H]Cl.[H]Cl.[H]Cl
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Synonyms
RK 20449 trihydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (12)
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Journal Impact Factor
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Most Recent
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Blood
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib. [Abstract]2016 Jun 23;127(25):3237-52. PMID: 27143257 -
Adv Sci (Weinh)
2025 Jun 30:e17764. PMID: 40586282 -
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J Med Chem
2024 Nov 28;67(22):20571-20579. PMID: 39513680 -
Commun Biol
Enhancing reprogramming towards induced human expanded pluripotency through substitution of SOX2 with engineered SOX17 transcription factors. [Abstract]2026 Apr 9;9(1):780. PMID: 41957290 -
Microb Pathog
Upregulation of haematopoetic cell kinase (Hck) activity by a secreted parasite effector protein (Ta9) drives proliferation of Theileria annulata-transformed leukocytes. [Abstract]2025 Feb:199:107252. PMID: 39730099 -
Biochem Biophys Res Commun
Hematopoietic cell kinase activation in skeletal myocytes contributes to local inflammation and pain sensitization in myofascial trigger points. [Abstract]2026 Aug 27:828:154112. PMID: 42269276 -
Res Sq
Cyclin-Dependent Kinase 5 Contributes to Bruton's Tyrosine Kinase Inhibitor Resistance via the IRE1α/XBP1 Axis in Mantle Cell Lymphoma. [Abstract]2026 May 8:rs.3.rs-9500406. PMID: 42147166 -
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Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (84.46 mM; Need ultrasonic)
DMSO : 1 mg/mL (1.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (168.92 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88. [Content Brief]
[2]. Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.6892 mL | 8.4459 mL | 16.8919 mL | 42.2297 mL |
| H2O | 5 mM | 0.3378 mL | 1.6892 mL | 3.3784 mL | 8.4459 mL |
| 10 mM | 0.1689 mL | 0.8446 mL | 1.6892 mL | 4.2230 mL | |
| 15 mM | 0.1126 mL | 0.5631 mL | 1.1261 mL | 2.8153 mL | |
| 20 mM | 0.0845 mL | 0.4223 mL | 0.8446 mL | 2.1115 mL | |
| 25 mM | 0.0676 mL | 0.3378 mL | 0.6757 mL | 1.6892 mL | |
| 30 mM | 0.0563 mL | 0.2815 mL | 0.5631 mL | 1.4077 mL | |
| 40 mM | 0.0422 mL | 0.2111 mL | 0.4223 mL | 1.0557 mL | |
| 50 mM | 0.0338 mL | 0.1689 mL | 0.3378 mL | 0.8446 mL | |
| 60 mM | 0.0282 mL | 0.1408 mL | 0.2815 mL | 0.7038 mL | |
| 80 mM | 0.0211 mL | 0.1056 mL | 0.2111 mL | 0.5279 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
A 419259 trihydrochloride Related Classifications
HY-15764A Related Classifications
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