1. Anti-infection
  2. Bacterial

Afabicin (Synonyms: Debio 1450; AFN-1720)

Cat. No.: HY-109000
Handling Instructions

Afabicin is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

For research use only. We do not sell to patients.

Afabicin Chemical Structure

Afabicin Chemical Structure

CAS No. : 1518800-35-5

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Afabicin is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

IC50 & Target

FabI, Bacterial[1]

In Vitro

Afabicin (Debio1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively. Debio1452 also inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0600 mL 10.3001 mL 20.6003 mL
5 mM 0.4120 mL 2.0600 mL 4.1201 mL
10 mM 0.2060 mL 1.0300 mL 2.0600 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

485.43

Formula

C₂₃H₂₄N₃O₇P

CAS No.

1518800-35-5

SMILES

O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Product Name:
Afabicin
Cat. No.:
HY-109000
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Afabicin

Cat. No.: HY-109000