1. Anti-infection
  2. Bacterial
  3. Afabicin

Afabicin (Synonyms: Debio 1450; AFN-1720)

Cat. No.: HY-109000
Handling Instructions

Afabicin (Debio 1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

For research use only. We do not sell to patients.

Afabicin Chemical Structure

Afabicin Chemical Structure

CAS No. : 1518800-35-5

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Description

Afabicin (Debio 1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci.

IC50 & Target

FabI, Bacterial[1]

In Vitro

Afabicin (Debio1450) is the prodrug of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 inhibits FabI, an enzyme critical to fatty acid biosynthesis in staphylococci. Debio1452 is highly active against staphylococci isolates, with MIC50 and MIC90 values of 0.015 μg/mL and 0.12 μg/mL, respectively. Debio1452 also inhibits S. aureus, with MICs of ≤0.12 μg/mL and MIC50 and MIC90 values of 0.004 μg/mL and 0.008 μg/mL, respectively[1].

Clinical Trial
Molecular Weight

485.43

Formula

C₂₃H₂₄N₃O₇P

CAS No.

1518800-35-5

SMILES

O=P(O)(O)OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AfabicinDebio 1450 AFN-1720Debio1450Debio-1450AFN1720AFN 1720AFN-1720BacterialInhibitorinhibitorinhibit

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Afabicin
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